Evaluation of contractile reserve by dobutamine echocardiography: noninvasive estimation of the severity of heart failure

American Heart Journal
A MarmorD Blondheim

Abstract

Functional status in chronic heart failure is evaluated in general by subjective means, such as the New York Heart Association class, or by invasive techniques difficult to use routinely. The aim of this study was to evaluate noninvasively the contractile reserve in cases of heart failure as a means to define the functional status of the patients. Cardiac peak power, a new noninvasively obtained afterload-independent index of contractility, was calculated from online Doppler and central arterial blood pressure estimated noninvasively in 35 patients with heart failure and 10 healthy subjects during dobutamine infusion. Cardiac output increased in all patients to the same extent, without differentiation among the functional classes. Contractile reserve, as assessed by peak power, was found to be a good marker of functional class: it was significantly higher in functional class 1 than in functional classes 2 through 4. A correlation of r = 0.99 and probability of p < 0.001 was found with the functional status. This new, noninvasive contractility index, peak power, allows an objective evaluation of the severity of heart failure.

References

Nov 1, 1978·Circulation Research·K Sagawa
Apr 1, 1987·Clinical Cardiology·A T MarmorD Front
Sep 1, 1994·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·A MarmorB Zaret

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Citations

Jan 29, 2002·European Journal of Heart Failure·Bruno PinamontiGianfranco Sinagra
Oct 5, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Frank Lloyd DiniMario Marzilli
Apr 29, 2006·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Ioannis A ParaskevaidisDimitrios Th Kremastinos
Feb 1, 1997·Journal of the American College of Cardiology·A Marmor, A Schneeweiss
May 3, 2016·Journal of Cardiopulmonary Rehabilitation and Prevention·Emre AslangerAlain Cohen-Solal

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