Abstract
Coronary artery calcium (CAC) scoring in the asymptomatic population can improve cardiovascular risk prediction. We aimed to assess CAC progression and the impact of coronary risk factors on the CAC progression rate in asymptomatic Korean individuals with a baseline CAC score of zero. The study population was derived from the Korea Initiatives on Coronary Artery Calcification (KOICA) registry: a retrospective, single ethnicity, multicenter registry of asymptomatic individuals who underwent CAC scoring as a part of a health checkup. Individuals with at least two CAC scores and an initial score of zero were included. CAC progression was defined as [√CAC score (follow-up) - √CAC score (baseline)] ≥2.5. The 10-year atherosclerotic cardiovascular disease (ASCVD) risk was calculated. Among 6,268 participants (mean age, 48.0±7.1 years; male, 80.5%), 719 (11.5%) experienced CAC progression during follow-up (median, 109 months; interquartile range, 78-208 months). The CAC progression rate was 0.3%, 1.9%, 4.3%, 8.6%, and 16.7% in years 1-5, respectively. The chance of CAC progression at 5 years was 13.1%, 22.0%, and 27.9% for individuals with a 10-year ASCVD risk of <5%, ≥5% but <7.5%, and ≥7.5%, respectively. A multivariable analysis re...Continue Reading
References
Mar 15, 1990·Journal of the American College of Cardiology·A S AgatstonR Detrano
Jul 19, 2003·Radiology·Leslee J ShawTracy Q Callister
Apr 22, 2004·AJR. American Journal of Roentgenology·John E HokansonMarian Rewers
Sep 6, 2005·Journal of the American College of Cardiology·Allen J TaylorPatrick G O'Malley
Aug 1, 2006·International Journal of Cardiology·Ambarish GopalMatthew J Budoff
May 16, 2007·Circulation·Richard A KronmalGregory L Burke
Mar 28, 2008·The New England Journal of Medicine·Robert DetranoRichard A Kronmal
Jun 13, 2009·JACC. Cardiovascular Imaging·Michael BlahaKhurram Nasir
Mar 13, 2010·Journal of the American College of Cardiology·James K MinTracy Q Callister
Apr 29, 2010·JAMA : the Journal of the American Medical Association·Tamar S PolonskyPhilip Greenland
Nov 6, 2010·Journal of the American College of Cardiology·John W McEvoySteven R Jones
Dec 18, 2010·JACC. Cardiovascular Imaging·Matthew J BudoffPaolo Raggi
Aug 23, 2012·JAMA : the Journal of the American Medical Association·Joseph YeboahDavid M Herrington
Mar 19, 2013·Journal of the American College of Cardiology·Matthew J BudoffNathan D Wong
Apr 25, 2013·Korean Circulation Journal·Iksung ChoDong-Ju Choi
Jul 16, 2013·Journal of Cardiovascular Computed Tomography·Matthew J BudoffUNKNOWN Multi-Ethnic Study of Atherosclerosis and the Investigator Group of the Heinz Nixdorf RECALL Study
Nov 14, 2013·Circulation·Neil J StoneUNKNOWN American College of Cardiology/American Heart Association Task Force on Practice Guidelines
Nov 14, 2013·Circulation·David C GoffGordon F Tomaselli
Jul 27, 2014·European Heart Journal·Raimund ErbelUNKNOWN Heinz Nixdorf Recall Study Investigators
Jul 21, 2015·JACC. Cardiovascular Imaging·Valentina ValentiJames K Min
Jan 13, 2016·Journal of cardiovascular ultrasound·Ji Hyun LeeHyuk-Jae Chang
Jul 4, 2016·JACC. Cardiovascular Imaging·Nina B RadfordBenjamin D Levine
Oct 28, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Ji Hyun LeeHyuk-Jae Chang
Feb 6, 2018·Journal of the American Society of Hypertension : JASH·Robert D Brook, Sanjay Rajagopalan
Feb 15, 2018·Korean Circulation Journal·Aeshita DwivediJames K Min