Evaluation of coxsackievirus and adenovirus receptor expression in human benign and malignant thyroid lesions

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Constantinos GiaginisStamatios Theocharis

Abstract

Coxsackievirus and adenovirus receptor (CAR) expression on tumor cells is associated with sensitivity to adenoviral infection, being considered as a surrogate marker for monitoring and/or predicting adenovirus-mediated gene therapy. The aim of this study was to evaluate the clinical significance of CAR expression in human benign and malignant thyroid lesions. CAR protein expression was assessed immunohistochemically on paraffin-embedded thyroid tissues from 107 patients with benign and malignant lesions and was statistically analyzed in relation to histopathologic type; tumor size; lymph node metastasis; capsular, lymphatic and vessel invasion; as well as follicular cells' proliferative capacity. CAR immunoreactivity was characterized as negative/weak in 53 (49.53%), moderate in 31 (28.97%) and strong in 23 (21.50%) of 107 thyroid cases. CAR immunoreactivity was significantly increased in malignant compared with that in benign thyroid lesions (p = 0.00002). Both malignant and benign thyroid lesions with enhanced follicular cells' proliferative capacity showed significantly increased CAR immunoreactivity (p = 0.00027). In malignant thyroid lesions, enhanced CAR immunoreactivity was significantly associated with larger tumor size...Continue Reading

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Citations

Apr 21, 2010·Pathology Oncology Research : POR·Christina MichailidiStamatios Theocharis
Mar 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Constantinos GiaginisStamatios Theocharis
Aug 30, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Nikolaos P KaridisStamatios Theocharis
Mar 31, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Constantinos GiaginisStamatios Theocharis
Oct 10, 2018·Gut·Mirjam B ZeiselThomas F Baumert

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