Evaluation of cross-protection against three topotypes of serotype O foot-and-mouth disease virus in pigs vaccinated with multi-epitope protein vaccine incorporated with poly(I:C)

Veterinary Microbiology
Yimei CaoZaixin Liu

Abstract

Epitope-based vaccines are always questioned for their cross-protection against the antigenically variable foot-and-mouth disease virus (FMDV). In this study, we proved the cross-protection effect of a multi-epitope vaccine incorporated with poly(I:C) against three topotypes of O type FMDV. A total of 45 naïve pigs were vaccinated with different doses of multi-epitope protein vaccine incorporated with poly(I:C). At 28 days post-vaccination, 45 vaccinated and 6 unvaccinated control pigs (two pigs for each group) were challenged with three topotypes of virulent O type FMDV, namely, O/Mya/98 (Southeast Asia topotype), O/HN/CHA/93 (Cathay topotype) and O/Tibet/CHA/99 (PanAsia topotype) strains. All unvaccinated pigs developed generalised FMD clinical signs. Results showed that all pigs (n=15) conferred complete protection against the O/Mya/98 and O/HN/CHA/93 FMDV strains, 11 of which were protected against the O/Tibet/CHA/99 FMDV strain. The 50% protective dose values of the vaccine against the O/Mya/98, O/HN/CHA/93 and O/Tibet/CHA/99 FMDV strains were 15.59, 15.59 and 7.05, respectively. Contact challenge experiment showed that transmission occurred from the donors to the unvaccinated but not to vaccinated pigs. These results show...Continue Reading

References

Jan 1, 1984·Journal of Biological Standardization·M M Rweyemamu, P J Hingley
Jan 1, 1993·Viral Immunology·A AlonsoF A Osorio
Mar 17, 2001·Intervirology·J I Sin, D B Weiner
Jun 10, 2006·Molecular Cell·Etienne Meylan, Jürg Tschopp
Dec 18, 2010·Expert Review of Vaccines·Zhiyong Li, Jixing Liu
Dec 1, 2011·Journal of Internal Medicine·C TrumpfhellerR M Steinman
Sep 7, 2013·Veterinary Research·Begoña Valdazo-GonzálezDonald P King

Citations

Jan 14, 2016·Expert Review of Vaccines·Yimei CaoZaixin Liu
Sep 23, 2014·Expert Review of Vaccines·Yimei Cao
May 9, 2014·Animal Health Research Reviews·Benjamin W NewcomerM Daniel Givens
Sep 26, 2020·Frontiers in Veterinary Science·Chuan Loo WongWen Siang Tan
Mar 16, 2018·Current Opinion in Virology·Teresa de Los SantosLuis L Rodriguez

Related Concepts

Metazoa
Antibodies, Viral
Antigenic Specificity
Foot-and-Mouth Disease
Poly I-C
Family suidae
Swine Diseases
Viral Vaccines
Foot-and-Mouth Disease Virus
Sus scrofa domestica

Related Feeds

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.