PMID: 15247813Jul 13, 2004Paper

Evaluation of current biological exposure index for occupational N, N-dimethylformamide exposure from synthetic leather workers

Journal of Occupational and Environmental Medicine
Ven-Shing WangChin-Chi Lin

Abstract

The aim of this study was (1) to investigate the correlation between external exposure to N, N-dimethylformamide (DMF) and urinary excretion of DMF and N-methylformamide; (2) to assess whether the correspondence between the current occupational exposure limit setting and recommended urinary biological exposure index is substantial; and (3) to evaluate whether coexposure to toluene, methyl ethyl ketone, and ethyl acetate has an effect on urinary excretion of DMF and N-methylformamide (NMF). Urinary DMF and NMF were significantly correlated (P < 0.01) with one another and also significantly correlated with airborne DMF (P < 0.01) over the range of 1.55 to 152.8 mg/m. Urinary DMF can be considered a complementary marker for short-term exposure. Urinary concentration of NMF and DMF, corresponding to the 8-hour exposure to airborne DMF at 30 mg/m, was estimated to 38.4 mg/L or 39.4 mg/g creatinine for NMF and to 0.92 mg/L or 0.96 mg/g creatinine for DMF.

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May 7, 2003·International Archives of Occupational and Environmental Health·Ho-Yuan ChangVen-Shing Wang

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Citations

Nov 12, 2009·Journal of Occupational and Environmental Hygiene·Ta-Yuan ChangChiu-Shong Liu
Jun 9, 2009·Journal of Occupational Health·Ta-Yuan ChangShou-Yu Lin
Jul 9, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Kristina Hennebrüder, Jürgen Angerer
Sep 28, 2012·Critical Reviews in Toxicology·Gerald L Kennedy

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