Evaluation of cytokines (MIG, IFN-gamma, TNF-alpha, IL-4, IL-5, and IL-10) during the different evolutive phases of chagasic esophagopathy

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Eduardo CremaVirmondes Rodrigues Júnior

Abstract

The production of cytokines (MIG, IFN-gamma, TNF-alpha, IL-4, IL-5, and IL-10) was studied in 39 individuals, including 28 with chagasic esophagopathy and 11 nonchagasic patients with gastroesophageal reflux disease. A sandwich enzyme immunoassay employing monoclonal antibody pairs specific for each cytokine was used. IFN-gamma and MIG production was significantly higher in patients with megaesophagus compared to control. Furthermore, in the absence of stimulation TNF-alpha levels were lower in the chagasic group than in the control group. In addition, significantly lower TNF-alpha levels were observed for the advanced form of the disease compared to the nonadvanced form. These results support the hypothesis that, although patients with advanced phase of megaesophagus present low number of CD4+ T lymphocytes, PBMC from this patients are able to respond up specific antigen stimulation.

References

Jan 1, 1997·Revista Do Instituto De Medicina Tropical De São Paulo·M de L Higuchi
Aug 1, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·I A Abrahamsohn
Aug 26, 1998·Clinical Immunology and Immunopathology·E M LemosR Correa-Oliveira
Jun 25, 1999·Revista Da Sociedade Brasileira De Medicina Tropical·L S WardR M Maciel

❮ Previous
Next ❯

Citations

Apr 14, 2009·Journal of Neurology·Jamary Oliveira-FilhoKaren L Furie
Jul 8, 2009·PLoS Neglected Tropical Diseases·Juliana de MeisWilson Savino
Mar 8, 2014·PloS One·Giovane Rodrigo SousaManoel Otávio da Costa Rocha
Jul 20, 2012·Clinical & Developmental Immunology·Denise Bertulucci Rocha RodriguesVirmondes Rodrigues
May 13, 2020·Infectious Diseases of Poverty·Fernanda Fortes de AraújoOlindo Assis Martins-Filho
Jun 3, 2021·Biology·Alejandro Diaz-HernandezAlejandro Carabarin-Lima

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.