Evaluation of cytotoxicity and anticonvulsant activity of some Iranian medicinal Ferula species

Pharmaceutical Biology
Seyyed Majid BagheriMehrdad Iranshahi

Abstract

Several Ferula (Umbelliferae) species have been used in Iranian traditional medicine as antiflatulent, antispasmodic, anticonvulsant, expectorant, etc. In the present study, cytotoxicity and anticonvulsant activity of the methanol extracts from several Ferula species were evaluated. Air-dried samples of different parts of these plants (Ferula diversivittata Regel & Schmalh. (roots), Ferula persica Willd. (aerial parts), Ferula ovina (Boiss.) Boiss. (roots), Ferula badrakema Kos.-Pol. (roots), Ferula diversivittata (flowers), Ferula latisecta Rech. F. & Aell. (roots), and Ferula badrakema (fruits)) were macerated with methanol for 3 days. The mixtures were then filtered, concentrated and dried. For determination of the cytotoxicity of the extracts and also the oleo-gum-resin of F. assafoetida L., the brine shrimp (Artemia salina) was employed as a model assay system since it provides a convenient in-house pre-screening method for evaluating general cytotoxicity. The methanol extracts of different Ferula species and the oleo-gum-resin of F. assafoetida exhibited cytotoxic effect with LC(50) values in the range of 6-321 microg/mL. For the anticonvulsant testing, seizure was induced by injection of pentylenetetrazole (PTZ), 90 mg/k...Continue Reading

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Citations

Sep 12, 2014·North American Journal of Medical Sciences·Seyyed Majid BagheriMansur Esmaili
Jul 5, 2015·Epilepsy & Behavior : E&B·Sitaram Jaideep SriranjiniVernekar Sanjeeva Mamta
Feb 15, 2014·Seizure : the Journal of the British Epilepsy Association·Shamim SahranavardMahmoud Mosaddegh
Mar 19, 2016·Natural Product Research·Seyed Mehdi RazaviSatyajit Dey Sarker
Dec 7, 2010·Journal of Ethnopharmacology·Milad Iranshahy, Mehrdad Iranshahi
Jan 28, 2015·Journal of Ayurveda and Integrative Medicine·Ali Fatahi BafghiSeyed Hassan Hejazian
Apr 15, 2016·Journal of Dietary Supplements·Mohaddese Mahboubi
Mar 20, 2015·American Journal of Alzheimer's Disease and Other Dementias·Seyyed Majid Bagheri, Mohammad Hossein Dashti-R
Oct 3, 2015·Journal of Evidence-based Complementary & Alternative Medicine·Seyyed Majid BagheriMohammad Hossein Dashti-R
Oct 13, 2019·Metabolic Brain Disease·Asmat Ullah KhanSaeed Ahmad
Apr 20, 2017·Oncotarget·Wei LiuBingjin Li
May 6, 2020·Mini Reviews in Medicinal Chemistry·Mohammad SabzehzariAmirhossein Sahebkar
May 21, 2021·Planta medica·Junchi WangJianyong Si
Oct 11, 2021·Veterinary Medicine and Science·Lei HuangKejiao Jiang

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