Evaluation of cytotoxicity, genotoxicity and teratogenicity of marine sediments from Qingdao coastal areas using in vitro fish cell assay, comet assay and zebrafish embryo test

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Fan YangShicui Zhang

Abstract

Marine sediments are often a final sink for numerous anthropogenic contaminants and may impose serious effects on benthic organisms and ecosystem. An in vitro cell assay using a cell line derived from flounder gill (FG) cells, an in vitro comet assay in FG cells, and an in vitro zebrafish embryo assay were used to evaluate the in vitro cytotoxicity (measured by MTT reduction), genotoxicity and teratogenicity of crude sediment extracts of Li Cang (LC), Zhan Qiao (ZQ) and Olympic Sailing Center (OSC) from Qingdao coastal area. Sediments from the three sites displayed different cytotoxicity, genotoxicity and teratogenicity potencies; however, all three assays yielded similar LOECs (lowest observed effect concentration) for each site, suggesting that the assays were equally sensitive to and suitable for initial screening of the LOECs of marine sediments. The cytotoxicity, genotoxicity and teratogenicity for these three sampling sites were in the same order of LC>ZQ>OSC, indicating different degrees of contamination. Interestingly, trials with the three sediment extracts at the doses inducing a similar cytotoxicity as evaluated with MTT reduction did not produce similar genotoxicity and teratogenicity, with the genotoxic and teratog...Continue Reading

References

Jan 1, 1992·Mutation Research·V Mersch-SundermannS Kevekordes
Mar 1, 1988·Experimental Cell Research·N P SinghE L Schneider
Jun 6, 2000·Mutation Research·U KammannH Steinhart
Mar 22, 2003·Marine Environmental Research·Kenneth Schiff, Steven Bay
Aug 2, 2003·Phytochemical Analysis : PCA·Snejana MonchevaSimon Trakhtenberg
Jul 28, 2004·Environmental Pollution·M NadalJ L Domingo
Feb 17, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M DavorenC Mothersill
Jan 28, 2006·The Science of the Total Environment·Nevenka BihariBlanka Kralj-Bilen
Jul 22, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Luka TravenVladimir Mićović
Mar 14, 2009·Environmental Science and Pollution Research International·Rhaul OliveiraAmadeu M V M Soares
May 26, 2009·Bulletin of Environmental Contamination and Toxicology·Ranu TripathiJai Raj Behari
Aug 5, 2009·Environmental Monitoring and Assessment·Sandro FroehnerKarina Scurupa Machado
Nov 13, 2009·The Science of the Total Environment·Cristiano V M AraújoIgnacio Moreno-Garrido
Jan 1, 1988·Toxicology in Vitro : an International Journal Published in Association with BIBRA·E BorenfreundN Martin-Alguacil

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Citations

Jan 17, 2014·Zebrafish·Sridhara ChakravarthySunil Kumar Sukumaran
Mar 25, 2014·Environmental Science and Pollution Research International·Caroline VignetXavier Cousin
Oct 10, 2013·Ecotoxicology and Environmental Safety·Ivančica TernjejNevenka Kopjar
Mar 1, 2016·Bioscience, Biotechnology, and Biochemistry·Kenji KuriyaKatsuzumi Okumura
Nov 19, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Debora LachnerClaudia B R Martinez
Jun 15, 2011·Birth Defects Research. Part C, Embryo Today : Reviews·Shaukat AliMichael K Richardson
Dec 3, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Manish Raj Pandey, Huarong Guo
Mar 29, 2013·Fish & Shellfish Immunology·Shousheng LiuShicui Zhang
Apr 8, 2014·Developmental and Comparative Immunology·Qiaoyan HuangZhenhui Liu
May 6, 2016·Environmental Science and Pollution Research International·Asli KacarFiliz Kucuksezgin
Aug 2, 2019·Plant Signaling & Behavior·Elif ÇakmakYıldız Aydın
Sep 7, 2020·Environmental Science and Pollution Research International·Baokai WeiYongjie Wei
Jul 1, 2019·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Bojana Žegura, Metka Filipič
Jun 29, 2021·The Science of the Total Environment·Patrícia SaikiThiago Lopes Rocha

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