Evaluation of damaged small intestine of mouse following methotrexate administration

Cancer Chemotherapy and Pharmacology
M NakamaruT Horie

Abstract

Methotrexate (MTX) treatment causes damage to the small intestine, resulting in malabsorption and diarrhea. The active and passive transport capacities of the small intestine are decreased by the treatment. The purpose of this study was to evaluate the damage to the small intestine of mice caused by MTX administration by examining the permeability of the paracellular pathway of the small intestinal epithelium. MTX was administered orally to male ddY mice once daily for 1-6 days. The permeability of the small intestine to the nonabsorbable markers phenol red (PR) and fluorescein isothiocyanate (FITC) dextrans was examined using everted segments of the intestine. PR and FITC dextran permeation through the small intestine increased significantly in parallel with changes in body weight of the mice, wet weight of the small intestine and chemical composition of the small intestinal epithelium. In addition to changes in permeation through the transcellular pathway reported previously, this study revealed that MTX treatment disorders the paracellular barrier function of the small intestinal epithelium, resulting in increased permeation of nonabsorbable markers via the paracellular pathway of the small intestinal mucosa. The present app...Continue Reading

Citations

Dec 16, 2000·Clinical and Experimental Pharmacology & Physiology·K NaruhashiT Hasegawa
Jul 30, 1999·Pharmacology & Toxicology·K Hirata, T Horie
Jul 6, 2005·Chemico-biological Interactions·Takashi Tomimatsu, Toshiharu Horie
Oct 9, 2002·Medicinal Research Reviews·Guofeng You
Dec 28, 2007·Pharmaceutical Research·Yogeeta NarkarJoseph R Robinson
Sep 17, 2009·Cancer Chemotherapy and Pharmacology·Tomoko MaedaToshiharu Horie
Jan 26, 2002·European Journal of Drug Metabolism and Pharmacokinetics·T KurodaM Akahori
Aug 16, 2003·British Journal of Clinical Pharmacology·Simon Smale, Ingvar Bjarnason
Apr 17, 2004·British Journal of Haematology·Michael Ellis
Nov 8, 2003·World Journal of Gastroenterology : WJG·Lian-An Ding, Jie-Shou Li
Mar 10, 2001·The Journal of Nutrition·T HorieT Fuwa
Jul 29, 2003·Journal of Pharmaceutical Sciences·Evelyn D Lobo, Joseph P Balthasar
Aug 24, 2021·BioMed Research International·Zhi-Xin LiYong-Qing Zeng

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