Evaluation of Definitive Stereotactic Body Radiotherapy and Outcomes in Adults With Extracranial Oligometastasis

JAMA Network Open
Ian PoonArjun Sahgal

Abstract

The outcomes and factors that influence survival in patients with oligometastasis (OM) are not well understood and have not been well described in large-scale studies. To evaluate overall progression-free survival (PFS), widespread progression (WSP) outcomes, and survival factors from a pooled data set of 1033 patients with OM treated with stereotactic body radiotherapy (SBRT). Case series from January 1, 2008, to December 31, 2016. The dates of analysis were April 2019 to May 2020. The setting was multi-institutional tertiary care hospitals. Participants were consecutive patients with 5 or fewer extracranial OMs whose primary tumor was treated curatively. Definitive SBRT. Overall survival (OS), progression-free survival, rate of WSP, patterns of failure, and factors altering OS. In the largest international OM case series to date (1033 participants) (mean age, 68.0 years [range, 18.0-94.3 years]; 601 [58.2%] men), 1416 SBRT courses were delivered to patients with 1 OM (596 [57.7%]), 2 OMs (245 [23.7%]), 3 OMs (105 [10.2%]), 4 OMs (55 [5.3%]), and 5 OMs (32 [3.1%]). The median follow-up was 24.1 months (range, 0.3-104.7 months), and the median OS was 44.2 months (95% CI, 39.2-48.8 months). The median PFS was 12.9 months (95% CI...Continue Reading

References

Jan 1, 1997·The Journal of Thoracic and Cardiovascular Surgery·U PastorinoUNKNOWN International Registry of Lung Metastases
Dec 17, 2011·International Journal of Radiation Oncology, Biology, Physics·Michael T MilanoPaul Okunieff
May 29, 2012·Clinical Oncology : a Journal of the Royal College of Radiologists·A SahgalUNKNOWN The Canadian Association of Radiation Oncology-Stereotactic Body Radiotherapy Task Force
Jun 25, 2014·Nature Reviews. Clinical Oncology·David A PalmaRalph Weichselbaum
Apr 29, 2016·Science·Samra Turajlic, Charles Swanton
Dec 15, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Piet OstGert De Meerleer
Oct 26, 2018·Lancet·Christopher C ParkerUNKNOWN Systemic Therapy for Advanced or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) investigators
Nov 8, 2018·Nature Reviews. Clinical Oncology·Eric D Brooks, Joe Y Chang
Apr 16, 2019·Lancet·Billy W Loo, Maximilian Diehn
May 9, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel R GomezJohn V Heymach
Jun 3, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David A PalmaSuresh Senan

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Citations

Jun 17, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philippe GirardNicolas Girard
Jun 14, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hendrick TanHany Soliman
Jul 17, 2021·Journal of Cancer Research and Clinical Oncology·Francesco CucciaFilippo Alongi
Jul 30, 2021·Acta Oncologica·Anita M Werensteijn-HoninghIna M Jürgenliemk-Schulz
Aug 25, 2021·Current Treatment Options in Oncology·Eric G NesbitJonathan B Strauss
Aug 30, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yilin CaoKristin J Redmond

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Methods Mentioned

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biopsy
imaging techniques

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