Evaluation of dermal wound healing activity and in vitro antibacterial and antioxidant activities of a new exopolysaccharide produced by Lactobacillus sp.Ca6

International Journal of Biological Macromolecules
Imen TrabelsiRiadh Ben Salah

Abstract

The present study aimed to evaluate the in vitro antibacterial and antioxidant activities and the in vivo wound healing performance of a noval exopolysaccharides (EPS-Ca6) produced by Lactobacillus sp.Ca6 strain. The results showed that EPS-Ca6 had a potential antioxidant activity determined through four different assays: DPPH scavenging activity, reducing power, β-carotene bleaching by linoleic acid assay, and Metal chelating activities. It also exhibited significant antibacterial activity against pathogenic bacteria Salmonella enterica and Micrococcus luteus. The wound healing activity of the EPS-Ca6, using excision wound model in rats, showed that this novel EPS accelerated significantly wound healing activity as compared to the control group, and a total closure was achieved after 14days of wound induction. Furthermore, histological examination of biopsies showed fully re-epithelialized wound with a complete epidermal regeneration. Overall the finding indicates that the EPS-Ca6 might be useful as a wound healing agent in modern medicine.

References

Oct 1, 1965·Histochemie. Histochemistry. Histochimie·J E Scott, J Dorling
Mar 20, 2002·Phytochemical Analysis : PCA·Irina I KolevaLyuba N Evstatieva
Jul 26, 2005·Journal of Ethnopharmacology·P J HoughtonA M Deters
Apr 20, 2010·Journal of Agricultural and Food Chemistry·Daniela TofaniAugusto Gambacorta
Jun 26, 2010·Journal of the American Academy of Dermatology·Stephan SchremlPhilipp Babilas
Aug 10, 2010·Nutrition·Thomas WildThomas Eberlein
Feb 5, 2011·Journal of Ethnopharmacology·Jacqueline Chor Wing TamClara Bik San Lau
Jan 20, 2015·International Journal of Biological Macromolecules·Imen TrabelsiBen Salah Riadh
Aug 27, 2015·International Journal of Biological Macromolecules·Imene AmmarMonia Ennouri

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Citations

Aug 11, 2018·Molecular Biology Reports·T G Sahana, P D Rekha
Jun 8, 2021·Frontiers in Microbiology·Abdelmoneim K AbdallaRichard Holley

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