Evaluation of different combinations of gated trapping, RF-only mode and trap compensation for in-field MALDI Fourier transform mass spectrometry

Journal of the American Society for Mass Spectrometry
Jonathon K GoodenM L Gross

Abstract

MALDI, while providing advantages such as the ability to do in-depth and repeated exploration of the sample, challenges the existing performance capabilities of Fourier transform mass spectrometry (FTMS). The challenge arises because MALDI-produced ions have high mass-to-charge ratios and uncertain kinetic-energy distributions. We demonstrate that a combination of a gated trapping event, a RF-only mode pressure focusing event, and an electrically compensated trap provides a compelling advantage in meeting these challenges. Removal of any of the above combination elements significantly degrades the detection performance of substance P from 850 K resolving power at 34.9 kHz and of melittin from 278 K resolving power at 16.5 kHz when using a 3-Tesla magnet-based spectrometer.

References

Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T Solouki, D H Russell
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·R T McIverR L Hunter
Jul 1, 1992·Journal of the American Society for Mass Spectrometry·D L Rempel, M L Gross

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Citations

Feb 26, 2008·Journal of the American Society for Mass Spectrometry·Aleksey V TolmachevRichard D Smith
Jul 5, 2008·Journal of the American Society for Mass Spectrometry·Adam M BrustkernMichael L Gross
Nov 18, 2008·Journal of the American Society for Mass Spectrometry·Konstantin AizikovPeter B O'Connor
Feb 10, 2009·Journal of the American Society for Mass Spectrometry·Nathan K KaiserJames E Bruce
Jan 12, 2010·Journal of the American Society for Mass Spectrometry·Adam M BrustkernMichael L Gross
Oct 5, 2010·Journal of the American Society for Mass Spectrometry·Sarfaraz U SyedStephen Taylor
Jan 24, 2012·Analytical Chemistry·Feng XianAlan G Marshall
Apr 19, 2011·International Journal of Mass Spectrometry·Adam M BrustkernMichael L Gross
Dec 18, 2013·Journal of Mass Spectrometry : JMS·S U A H SyedS Taylor
Sep 23, 2020·Mass Spectrometry Reviews·Michael L Gross, Don L Rempel
May 10, 2005·Journal of Mass Spectrometry : JMS

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