PMID: 6975788Jan 1, 1981Paper

Evaluation of different methods for detecting circulating immune complexes. Studies in patients with lung cancer

Journal of Immunological Methods
G FüstM Misz

Abstract

In a collaborative study involving 7 laboratories, sera from 53 patients with lung cancer, 37 primary and 16 secondary tumours, and sera of 40 healthy blood donors were tested by 19 different assays or assay modifications used for detecting immune complexes. In 12 out of 19 assays, significantly higher immune complex levels were found in the cancer patients than in the healthy subjects. Assays based on interactions between immune complexes and Fc receptors of different cells (lymphocytes, macrophages of platelets) discriminated between cancer patients and health subjects and a high percentage (47-87%) of positivity was observed in such assays in patients with lung cancer. In contrast, none of the tests based on immune complex-complement interactions discriminated between cancer patients and health subjects. Immunochemical analyses of the PEG precipitates obtained from the sera tested revealed that the concentrations of IgG, IgA and C3 were significantly higher in the precipitates obtained from patients sera than from control sera, but no significant differences were seen in IgM and C1q concentrations. A 100% correct classification of individuals tested was obtained on discriminant analysis of results with 3 assays: EA rosette i...Continue Reading

References

Jan 1, 1979·Journal of Immunological Methods·K MereteyS Bozsoky
Dec 15, 1977·International Journal of Cancer. Journal International Du Cancer·H E HeierT Godal
Nov 15, 1979·International Journal of Cancer. Journal International Du Cancer·P K Poskitt, T R Poskitt
Jan 1, 1973·European Journal of Immunology·P Brain, R H Marston
Sep 1, 1970·Cellular Immunology·P Perlmann, H Perlmann
Jan 1, 1980·Oncology·M Pavone-Macaluso, G B Ingargiola

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Citations

Jan 1, 1995·Acta neurochirurgica·S ManjulaA Rao
Nov 1, 1991·Japanese Journal of Cancer Research : Gann·T K DassA Rattan
Apr 14, 2011·Nature Reviews. Molecular Cell Biology·Karl S Matlin
Jan 1, 1983·Immunological Communications·W M Siag, J M Jones
Jun 1, 1985·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·E Rødahl

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