Evaluation of different methods of leukoreduction of donor platelets to prevent alloimmune platelet refractoriness and induce tolerance in a canine transfusion model.

Blood
S J SlichterDoug Bolgiano

Abstract

The effectiveness of different methods of leukoreduction in preventing alloimmune platelet refractoriness was evaluated in a canine model. Platelets from a random donor dog were administered for up to 8 weeks or until platelet refractoriness. Standard (STD; unmodified) platelets were accepted by 14% of recipients (n = 7) compared with 14% for centrifuge leukoreduced (C-LR) platelets (n = 21) and 31% for filter leukoreduced (F-LR) platelets (n = 13; no significant differences). Surprisingly, using both F-LR and C-LR platelets was highly effective (87% acceptance, n = 15). Transfusing F-LR/C-LR red blood cells (n = 4) or F-LR/C-LR plasma (n = 4), along with F-LR/C-LR platelets, did not affect platelet acceptance (100% acceptance). Overall acceptance of F-LR/C-LR platelets was 91% (n = 23; P < or = .05 versus STD, C-LR, or F-LR platelets). F-LR/C-LR transfusions also induced tolerance to subsequent STD platelet transfusions from the same donor (82% acceptance, n = 19) as well as to donor skin grafts without recipient immunosuppression (57% acceptance, n = 7). To evaluate mechanisms of tolerance induction, F-LR/C-LR platelets were gamma-irradiated. Although the gamma-irradiated F-LR/C-LR platelets were uniformly accepted (n = 6), t...Continue Reading

References

Oct 1, 1990·Transfusion Medicine Reviews·T S Kickler
Sep 1, 1986·Transfusion·A BrandJ G Eernisse
Aug 1, 1986·British Journal of Haematology·S J SlichterM L Schroeder
May 1, 1982·British Journal of Haematology·K A SchwartzL A Harker
Mar 1, 1995·Blood Reviews·D R Norfolk, L M Williamson
Jan 1, 1994·Transfusion Medicine Reviews·J J FreedmanN McCombie
Jan 7, 1998·The New England Journal of Medicine·UNKNOWN Trial to Reduce Alloimmunization to Platelets Study Group
Jul 31, 1998·Transfusion·S O Sowemimo-CokerB Wenz

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Citations

Jul 23, 2011·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Axel Seltsam, Thomas H Müller
Oct 5, 2013·Transfusion Medicine Reviews·Seema R Patel, James C Zimring
Oct 14, 2009·Journal of Veterinary Emergency and Critical Care·Mary Beth CallanBruce S Sachais
Jun 20, 2008·Transfusion·Mary Beth CallanReid P Groman
Jul 3, 2015·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Alexis J PerrosMelinda M Dean

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