PMID: 8949640Sep 1, 1996Paper

Evaluation of differential disaccharide excretion in urine for non-invasive investigation of altered intestinal disaccharidase activity caused by alpha-glucosidase inhibition, primary hypolactasia, and coeliac disease

Gut
I BjarnasonI S Menzies

Abstract

The reliability of a quantitative method for the non-invasive assessment of intestinal disaccharide hydrolysis was assessed. Differential excretion of intact disaccharide, expressed as ratios of lactulose to appropriate hydrolysable disaccharides in urine collected following combined ingestion, has been investigated in healthy volunteers with drug induced alpha-glucosidase inhibition, in subjects with primary hypolactasia, and patients with coeliac disease. Oral administration of the alpha-glucosidase inhibitor 'Acarbose' (BAY g 5421, 200 mg) together with sucrose and lactulose increased the urinary sucrose/lactulose excretion ratios (% dose/10 h) fivefold. The effect was quantitatively reproducible, a higher dose of 'Acarbose' (500 mg) increasing the excretion ratio to about 1.0 indicating complete inhibition of intestinal sucrase activity. The suitability of the method for measuring differences in dose/response and duration of action was assessed by comparing three different alpha-glucosidase inhibitors (BAY g 5421, BAY m 1099, and BAY o 1248) and found to be satisfactory. Subjects with primary adult hypolactasia had urine lactose/lactulose excretion ratios raised to values indicating reduced rather than complete absence of l...Continue Reading

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Citations

Aug 5, 1998·Alimentary Pharmacology & Therapeutics·N M Davies
Nov 1, 2012·Journal of Pediatric Gastroenterology and Nutrition·William R Treem
Jul 7, 2007·Scandinavian Journal of Gastroenterology·Ingvar Bjarnason
Sep 14, 2006·European Journal of Clinical Investigation·H A KoetseF Stellaard
Sep 17, 2013·Clinical and Experimental Pharmacology & Physiology·Ivana R SequeiraRoger D Hurst
Jun 1, 1997·Genitourinary Medicine·R Mak
Feb 1, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Natasa TasevskaVictor Kipnis

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