Evaluation of diffusion of triamcinolone acetonide from the distal interphalangeal joint into the navicular bursa in horses

American Journal of Veterinary Research
M BoyceT N Trumble

Abstract

To determine whether triamcinolone acetonide diffuses from the distal interphalangeal joint (DIPJ) to the navicular bursa, diffusion is direct or systemic, and addition of sodium hyaluronan has an effect on diffusion in horses. 11 adult horses without forelimb lameness. 1 randomly chosen forelimb DIPJ of each horse received an injection of 10 mg of triamcinolone acetonide plus 20 mg of sodium hyaluronan (group 1), and the contralateral forelimb DIPJ received an injection of 10 mg of triamcinolone acetonide plus 2 mL of lactated Ringer's solution (group 2). Synovial fluid samples were taken from both forelimb navicular bursae and 1 hind limb navicular bursa (systemic control group) at 6 hours. Triamcinolone acetonide concentrations in synovial fluid were quantified by use of high-performance liquid chromatography plus tandem mass spectrometry. Data were logarithmically transformed, and contrast analysis was performed on the 3 groups. Triamcinolone acetonide was detected in navicular bursal samples in all groups. Groups 1 and 2 had significantly greater concentrations of triamcinolone acetonide than the systemic control group. There was no significant difference between groups 1 and 2. Triamcinolone acetonide diffused directly fr...Continue Reading

References

Sep 1, 1992·Journal of Veterinary Pharmacology and Therapeutics·C L ChenJ Wiegand
Mar 1, 1986·Clinical Pharmacology and Therapeutics·H DerendorfG Gyselby
Jan 1, 1985·European Journal of Clinical Pharmacology·H MöllmannH Derendorf
Jul 15, 1970·European Journal of Pharmacology·P A JanssenW K Schaper
Mar 1, 1995·Journal of Clinical Pharmacology·H DerendorfM Erdmann
Sep 1, 1995·Equine Veterinary Journal·K J Dik, J van den Broek
Nov 5, 1997·Equine Veterinary Journal·D D FrisbieC W McIlwraith
Apr 25, 2001·Journal of Chromatography. B, Biomedical Sciences and Applications·P W TangT S Wan
May 12, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·F C RobionS Laverty
Jan 31, 2002·Equine Veterinary Journal·M R GoughG Mayhew
Feb 15, 2002·American Journal of Veterinary Research·Katharina L LohmannAllen J Roussel
Mar 1, 2003·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·D W Richardson, G R Dodge
May 12, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Christophe CélesteSheila Laverty
Aug 23, 2005·American Journal of Veterinary Research·Mike J SchoonoverMargaret A Blaik
May 2, 2008·American Journal of Veterinary Research·Frederik E PauwelsChris W Rogers

❮ Previous
Next ❯

Citations

Apr 10, 2014·Journal of Analytical Toxicology·Karan AgrawalKaryn Bischoff
Nov 4, 2016·Anatomia, histologia, embryologia·R PerrinJ M Vandeweerd
Jan 28, 2017·Equine Veterinary Journal·K NottrottM Schramme
Jan 5, 2019·Anatomia, histologia, embryologia·Fanny HontoirJean-Michel E Vandeweerd
Aug 28, 2020·Frontiers in Veterinary Science·Stasia N SullivanSushmitha S Durgam
Jan 23, 2021·American Journal of Veterinary Research·Stasia N SullivanSushmitha Durgam
Dec 25, 2012·The Veterinary Record·R Labens, W R Redding
Nov 9, 2012·The Veterinary Record·J M ManfrediT N Trumble

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.