Evaluation of difloxacin in the treatment of uncomplicated urethral gonorrhea in men.

Antimicrobial Agents and Chemotherapy
B L SmithW M McCormack

Abstract

Difloxacin is a new quinolone antimicrobial agent with in vitro activity against both Neisseria gonorrhoeae and Chlamydia trachomatis and a long (26-h) half-life. A single oral dose of 200 mg of difloxacin was used to treat 30 men with uncomplicated urethral gonorrhea in an open trial. Of the isolates of N. gonorrhoeae, three produced penicillinase and two were resistant to tetracycline. N. gonorrhoeae was eradicated from all 29 evaluable patients. The geometric mean MIC of difloxacin for 30 pretreatment N. gonorrhoeae isolates was 0.014 (range, less than or equal to 0.0039 to 0.03) microgram/ml. Four (13.3%) of the 30 subjects with gonococcal urethritis also had C. trachomatis recovered from their pretreatment cultures. Treatment with difloxacin was associated with the eradication of C. trachomatis from all four men. In addition, C. trachomatis was isolated from the posttreatment culture of only one man who had a negative culture before treatment. Nineteen patients (65.5%) reported adverse experiences, and 17 of them (58.6%) developed symptoms suggestive of central nervous system dysfunction. An oral dose of 200 mg of difloxacin is effective treatment for uncomplicated urethral gonorrhea and may also eliminate a coexisting inf...Continue Reading

References

Feb 1, 1979·Journal of Clinical Microbiology·K MontgomeryW L Drew
Jun 5, 1975·The New England Journal of Medicine·K K HolmesE R Alexander
Apr 1, 1975·The Journal of Infectious Diseases·J D OrielC S Nicol
Feb 1, 1985·Annals of Internal Medicine·E W Hook, K K Holmes
Apr 1, 1972·Antimicrobial Agents and Chemotherapy·C H O'CallaghanA H Shingler
Aug 12, 1982·The New England Journal of Medicine·W M McCormack
Mar 1, 1984·The New England Journal of Medicine·W E StammW M McCormack

❮ Previous
Next ❯

Citations

Apr 23, 2004·Expert Opinion on Pharmacotherapy·Michael Dan
Nov 7, 2019·Neurourology and Urodynamics·Tomonori MinagawaOsamu Ishizuka
Mar 29, 2000·The Journal of Urology·A F Morey, J W McAninch
Jan 27, 2019·The Cochrane Database of Systematic Reviews·Carol Páez-CanroHernando G Gaitán

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.