Evaluation of direct oral anticoagulants and vitamin K antagonists in mesenteric venous thrombosis

Phlebology
Saman SalimS Acosta

Abstract

Mesenteric venous thrombosis is a rare lethal disease. The main aim of the present study was to evaluate clinical efficacy and safety of direct oral anticoagulants and vitamin K antagonists in mesenteric venous thrombosis patients. Retrospective study of 102 mesenteric venous thrombosis patients treated between 2004 and 2017 at a center with a conservative medical first approach. Median clinical follow-up was 4 years. Computed tomography showed successful recanalization of thrombosis in 71% of patients on vitamin K antagonists and 69% of patients on direct oral anticoagulants ( p = 0.88). Overall major and esophageal variceal bleeding rate was 14.7% and 2.9%, respectively. No difference in major bleeding ( p = 0.54) was found between vitamin K antagonists and direct oral anticoagulants. No mesenteric venous thrombosis recurrence occurred during follow-up, and one venous thromboembolism occurred after cessation of anticoagulation. Anticoagulation with direct oral anticoagulants and vitamin K antagonists was efficient in patients with mesenteric venous thrombosis. Bleeding complications was a concern during treatment in both groups.

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Citations

Mar 14, 2020·Journal of Clinical Medicine·Nicoletta Riva, Walter Ageno
Oct 30, 2020·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·S Acosta, S Salim
Jan 21, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Andrew S MillerDanette Wright
Mar 19, 2021·Research and Practice in Thrombosis and Haemostasis·Nicoletta Riva, Walter Ageno

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