PMID: 9450505Feb 5, 1998Paper

Evaluation of dose-dependent pharmacokinetics of cocaethylene and cocaine in conscious dogs

Life Sciences
R B ParkerJ J Lima

Abstract

Cocaine use continues to be widespread in the United States. Most cocaine users co-ingest ethanol resulting in decreased elimination of cocaine and formation of the active cocaine metabolite, cocaethylene, by hepatic carboxylesterases. In a recent study from our laboratory in dogs to evaluate the cocaine-ethanol interaction, we demonstrated a similar ethanol-induced reduction in cocaine metabolism, although we were unable to detect cocaethylene when the two drugs were given together. This unexpected finding could be explained by ethanol-induced inhibition of cocaine metabolism via a pathway that does not involve hepatic carboxylesterases or formation of cocaethylene that inhibits cocaine metabolism and is then rapidly cleared. The purpose of the present study is to determine which of these mechanisms best explain our data by characterizing the pharmacokinetics of cocaine and cocaethylene over a range of doses in conscious dogs. Seven adult mongrel dogs received 1, 3, and 5 mg/kg cocaine and cocaethylene HCl base with each drug dose administered i.v. on a separate study day. Arterial blood samples were collected at various times after each dose and analyzed for cocaine and cocaethylene by HPLC. Cocaine clearance was dose-depende...Continue Reading

References

May 1, 1977·Life Sciences·D J StewartW Kalow
Nov 1, 1992·Toxicology and Applied Pharmacology·R A DeanW F Bosron
Feb 1, 1991·Pharmacology, Biochemistry, and Behavior·T H KellyM W Fischman
Mar 1, 1990·Circulation·T D FrakerR D Wilkerson
Jan 1, 1987·Journal of Pharmaceutical Sciences·M KhanC T Hung
Mar 1, 1981·Journal of Ethnopharmacology·G BarnettR Resnick

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Citations

Jun 18, 1999·Life Sciences·N SongS C Laizure
Nov 14, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·S Casey Laizure, Robert B Parker
Nov 19, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Robert B Parker, S Casey Laizure
Oct 6, 2005·Respiratory Physiology & Neurobiology·J Soliz, V Joseph
Jun 15, 2007·International Journal of Toxicology·Maria StefanidouHara Spiliopoulou
Apr 2, 2014·Journal of Speech, Language, and Hearing Research : JSLHR·Adam LammertShrikanth Narayanan
Dec 18, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·S Casey LaizureRobert B Parker
Feb 21, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Chyan E Lau, Lei Sun

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