Evaluation of dose enhancement in presence of gold nanoparticles in eye brachytherapy by 103 Pd source

Australasian Physical & Engineering Sciences in Medicine
Hadi RezaeiHesameddin Mostaghimi

Abstract

In recent years, the use of gold nanoparticles in radiation therapy has been introduced as a new approach in radiotherapy. The aim of this study is to investigate the effect of gold nanoparticles (GNPs) in plaque brachytherapy for choroidal melanoma using Monte Carlo (MC) simulation. MCNPX code was used for simulation of human eye, 103Pd (model 200) brachytherapy source and the 20 mm COMS eye plaque that was loaded with 24 103Pd seeds and standardized by Collaborative Ocular Melanoma Study (COMS). The tumour was defined from the inner surface of choroid with 0.55 cm height and latticed with gold nanospheres and it was filled with different concentrations of 5, 10 and 15 mg/g GNPs, separately. Dose rate and dose enhancement factor in tumour and normal tissues of the eye (without gold) was examined for this case and compared with gold-water mixture of the same concentrations distributed in the tumour. The results show that with increasing the concentration of GNPs, the dose in the tumour increases and the dose to the normal tissues decreases. Furthermore, the time that is required to deliver the prescribed dose to the tumour decreases. In the gold nanosphere case for 5, 10 and 15 mg/g concentrations, the DEF in the apex of the tu...Continue Reading

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Citations

May 17, 2018·Medicinal Research Reviews·Florence MasseElodie Boisselier
Mar 27, 2021·Current Opinion in Ophthalmology·David A Reichstein, Anderson L Brock
Jul 9, 2021·Nuclear Medicine and Biology·Noami DaemsAn Aerts
Jul 23, 2021·Progress in Retinal and Eye Research·Raphael LejoyeuxJay Chhablani
Jul 23, 2021·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Samira KamraniSamaneh Hashemi

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Methods Mentioned

BETA
X-ray

Software Mentioned

MCNPX
COMS
Geant4

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