Evaluation of dosing interval and optimum dose of cibenzoline

Journal of Clinical Pharmacology
P ZempolJ C Somberg

Abstract

Fifteen patients with ventricular premature complexes (VPCs) were included in this open study designed to assess the relative efficacy of bid (two times daily) and tid (three times daily) dosing regimens for cibenzoline as compared with qid (four times daily) administration. Patients started therapy with qid administration; this was followed in sequence by tid and bid administration at the maximum effective total daily dose determined during the qid administration. Of the nine patients evaluated for efficacy for suppression of VPCs, eight demonstrated a 75% or greater suppression of VPCs with cibenzoline administered qid (total daily dose of 130-325 mg). This effectiveness was maintained in four patients with a bid regimen and in three with a tid regimen. All four patients who had ventricular tachycardia (VT) had a decrease in the number of VT episodes while receiving cibenzoline (only one of these patients had satisfactory suppression of VPCs at the same dosage regimen). Twelve patients continued to receive extended therapy with cibenzoline for up to two years, as this was considered to be the optimum antiarrhythmic treatment for these patients. Two patients had to be removed from the study and two had the dosage lowered becau...Continue Reading

References

Mar 1, 1985·Clinical Pharmacokinetics·R K BrazzellP Block
Mar 1, 1984·Journal of Cardiovascular Pharmacology·K H Dangman
Aug 1, 1984·Journal of the American College of Cardiology·J B KostisN Cosgrove
Oct 1, 1984·Journal of Clinical Pharmacology·G KerenJ Somberg
Jul 1, 1983·British Journal of Pharmacology·J S Millar, E M Vaughan Williams
Mar 1, 1984·Journal of the American College of Cardiology·K F BrowneJ J Heger
Mar 1, 1984·Clinical Pharmacology and Therapeutics·R K BrazzellJ Morganroth

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