Evaluation of drug delivery characteristics of microspheres of PMMA-PCL-cholesterol obtained by supercritical-CO2 impregnation and by dissolution-evaporation techniques

Journal of Controlled Release : Official Journal of the Controlled Release Society
Carlos ElviraConcepción Domingo

Abstract

Poly(methyl methacrylate), PMMA, and of PMMA/Poly(epsilon-caprolactone), PCL, microspheres were loaded with different amounts of cholesterol by using a supercritical carbon dioxide (SC-CO2) impregnation process in order to use a clean technique with the absence of organic solvents, and to provide information for the infusion of additives into nonporous polymeric substrates. A conventional dissolution-evaporation method was also used to obtain PMMA and PMMA-PCL microparticles loaded with cholesterol. The obtained microspheres were characterized by environmental scanning electronic microscope, ESEM, nuclear magnetic resonance spectroscopy, NMR, and differential scanning calorimetry, DSC, thermal analysis. A comparison of drug release from particles obtained using both methods, the supercritical and the conventional, is presented.

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Citations

Mar 23, 2011·Journal of Materials Science. Materials in Medicine·Hernán E RomeoMaría A Fanovich
Jan 19, 2012·Journal of Microencapsulation·Ana Bettencourt, António J Almeida
Mar 5, 2009·Drug Development and Industrial Pharmacy·A CosijnsJ P Remon
Sep 18, 2010·Journal of Pharmaceutical Sciences·Anna ArgemíDavid L Tomasko
Jan 27, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Jayanta Kumar BalAlain Gibaud
Aug 8, 2009·Journal of Pharmaceutical and Biomedical Analysis·Anna ArgemíJavier Saurina
Oct 21, 2015·International Journal of Pharmaceutics·Peter VeresConcepción Domingo
Aug 19, 2008·International Journal of Pharmaceutics·Ming LiDenis Poncelet
Dec 22, 2005·International Journal of Pharmaceutics·Ana Rita C DuarteCatarina M M Duarte
Oct 6, 2012·Pharmaceutical Development and Technology·Priti GirotraKalpana Nagpal
May 9, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·M ChampeauC Jérôme
Aug 20, 2016·Journal of Materials Science. Materials in Medicine·Anastasia V CherkasovaAnna B Solovieva
Oct 25, 2016·International Journal of Pharmaceutics·Alexandre A BarrosRui L Reis
Jul 29, 2017·Advanced Healthcare Materials·Ranjith Kumar KankalaAi-Zheng Chen
Apr 23, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Firdos Alam KhanAbdelhamid Elaissari
May 13, 2010·Journal of Microencapsulation·A BettencourtA J Almeida
Mar 7, 2013·Science and Technology of Advanced Materials·So-Ra SonByong-Taek Lee
Dec 14, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·R SrikarE Kelley

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