Evaluation of DuraGen in preventing peridural fibrosis in rabbits. Invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2005

Journal of Neurosurgery. Spine
Claudio E TatsuiAllan D Levi

Abstract

Peridural fibrosis is the scar tissue formed over the dura mater after a laminectomy. It has been implicated as a cause of persistence of pain after spinal surgery and associated with increased risk of complications during revision surgery. The application of a mechanical barrier to cover the peridural space to block the migration of inflammatory cells from superficial layers to the epidural space can potentially prevent or decrease scar formation. The authors evaluated the use of DuraGen for this purpose. Seventeen New Zealand White rabbits underwent bilateral L-4 and L-7 laminectomies. Each space was randomly assigned to either receive DuraGen, fat graft, or no (sham) treatment. At a mean 18 +/- 4 weeks after surgery, the animals underwent magnetic resonance (MR) imaging with and without Gd enhancement, and the area of the scar tissue overlying the middle of the laminectomy was measured. The rabbits were killed and the spinal cords with an intact dural covering were harvested. The midsection of each treated level was evaluated histologically and the scar area was measured. In rabbits in which a fat graft was placed, MR imaging of the epidural space demonstrated a significant (p < 0.05) increase in the mean area (0.9713 mm2) o...Continue Reading

References

Feb 1, 1978·Journal of Neurosurgery·J D LawW M Kirsch
Mar 1, 1995·Journal of Neurosurgery·P K NarotamK D Bhoola
Jan 1, 1993·Acta neurochirurgica·J VaqueroM Zurita
Jun 10, 1998·The Journal of Bone and Joint Surgery. British Volume·J J QuistA J Verbout
Apr 24, 1999·Neurological Research·M Samy Abdou, R W Hardy
Jul 25, 2000·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·E CoskunK Tahta
Feb 13, 2003·Archives of Orthopaedic and Trauma Surgery·Dirk GanzerHarry Merk
Jul 16, 2003·Journal of Neurosurgery·Fikret DoguluNecdet Ceviker
Oct 10, 2003·Neurosurgical Review·Aşkin GörgülüTurgay Parsak
Nov 1, 2003·The Spine Journal : Official Journal of the North American Spine Society·Kathleen E RodgersRichard A Berg
Dec 4, 2003·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Zhenglin LiKouichiro Toyoda
Jan 30, 2004·Journal of Neurosurgery·Jin-Yul LeeNorfrid Klug
Sep 25, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hsin-Nung ShihLih-Yuann Shih
Nov 4, 2004·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Metin Gungormus

❮ Previous
Next ❯

Citations

Jan 4, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Manuel A Sandoval, Daniel Hernandez-Vaquero
Oct 24, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Katarina RönnbergH Brisby
May 1, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Huiren Tao, Hongbin Fan
Dec 20, 2011·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·S Raysi DehcordiR J Galzio
Apr 25, 2012·Annals of Biomedical Engineering·Devendra VermaNoshir Langrana
May 1, 2012·Journal of Neurosurgery. Spine·Paul McMahonAllan D Levi
Nov 29, 2011·World Neurosurgery·José Humberto Sandoval-SánchezGuadalupe Jorge-Espinoza
Nov 21, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Peter J RichardsJason Schense
Dec 3, 2014·The Spine Journal : Official Journal of the North American Spine Society·Bora GürerAysun Gökçe
Sep 21, 2016·Journal of Materials Science. Materials in Medicine·Sung Joon ShinKyungdan Min
Apr 7, 2018·Journal of Orthopaedic Surgery and Research·Juan N Albiñana-CunninghamMatías Alfonso-Olmos
Mar 6, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Xiaolei LiMing Pei
Feb 26, 2020·Acta ortopedica brasileira·Serkan GulerDeniz Cankaya
Nov 17, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Sophia ShahRoman J Krawetz

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection

Software Mentioned

neurolucida
Image J

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.