Evaluation of early events in the creation of amyenteric opossum model of achalasia

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
C SingaramR L Snipes

Abstract

Benzyldimethyltetradecylammonium chloride (BAC) has previously been used to create amyenteric rat jejunal models. Fifteen opossums (D. virginiana) were injected with 10-15 mL 4 mM BAC or saline in the distal oesophagus and along with controls underwent oesophagoscopy, manometry and barium oesophagrams. Atropine and sodium nitroprusside were studied in six of the BAC-treated and five controls using oesophageal manometry. Histologically several neuronal markers, B-NADPH-diaphorase and acetylcholine esterase histochemical staining were used. NADPH-diaphorase activity was assayed at the lower oesophageal sphincter (LOS) and 3 and 5 cm above LOS in both groups. Oesophagoscopy of the treated animals showed no mucosal inflammation, or strictures. Manometrically, LOS pressures were significantly higher in the BAC-treated group (25.7 +/- 8.6 mmHg) when compared to controls (8.7 +/- 1.8 mmHg). The oesophageal contraction amplitudes were similar in both groups. While sodium nitroprusside (SNP) significantly reduced the LOS pressure, atropine did not alter the resting LOS pressure in the BAC-treated animals. Histologically at the LOS the treated group showed: (i) absence of myenteric neurons, in contrast to prominent NADPH-diaphorase and o...Continue Reading

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Citations

Jul 20, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y-Q ZhuN-W Chen
Jan 25, 2014·Veterinary Pathology·J PangJ G Fox
Jun 3, 2005·The American Journal of Gastroenterology·Woosuk Park, Michael F Vaezi
Oct 28, 2009·World Journal of Gastroenterology : WJG·Javad MikaeliReza Malekzadeh
Sep 28, 2016·World Journal of Gastroenterology : WJG·Janette Furuzawa-CarballedaGonzalo Torres-Villalobos

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