Evaluation of early graft function by hepatic venous hemoglobin oxygen saturation following orthotopic liver transplantation in the rat

Transplantation
H ShimizuN Nakajima

Abstract

This study was designed to evaluate the use of hepatic venous oxygen saturation (Shvo2) as a predictor of early graft function after liver transplantation. We examined the levels of Shvo2 and serum ALT after transplantation using the isogeneic rat orthotopic liver transplant model. Shvo2 levels 2 hr after reperfusion in the 6-hr cold ischemia (nonviable allograft) group were significantly lower than those in the 1-hr and 3-hr cold ischemia (viable allograft) groups. However, there was no significant difference in ALT levels among these groups. These results suggest that decreased hepatic blood flow due to microcirculatory disturbances may occur in the nonviable allograft even in the early phase of reperfusion and may be responsible for ischemic damage to parenchymal cells. Therefore, Shvo2 could provide a simple index of the initial graft status and be useful for a rapid etiological diagnosis of early postoperative graft dysfunction and for estimating the graft outcome after liver transplantation.

References

Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T IkedaK Sugimachi
Nov 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H ShimizuR E Falk
Sep 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R CywesS M Strasberg

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Citations

Feb 18, 2011·Langenbeck's Archives of Surgery·Leif JanssonOrjan Källskog
Sep 12, 2000·Acta Anaesthesiologica Scandinavica·I KogaL Wiklund
Dec 31, 1998·Transplant International : Official Journal of the European Society for Organ Transplantation·K IwanamiY Morishita
Dec 28, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C JiaS Zheng
May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S YoshiokaY Fukuda

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