Evaluation of Early Response to Treatment of Hepatocellular Carcinoma with Yttrium-90 Radioembolization Using Quantitative Computed Tomography Analysis

Korean Journal of Radiology : Official Journal of the Korean Radiological Society
Sungwon KimJin Young Choi

Abstract

To identify an imaging predictor for the assessment of early treatment response to yttrium-90 transarterial radioembolization (TARE) in patients with hepatocellular carcinoma (HCC), using a quantitative assessment of dynamic computed tomography (CT) images. Dynamic contrast-enhanced CT was obtained pre- and 4 weeks post-TARE in 44 patients (34 men, 10 women; mean age, 60 years) with HCC. Computer software was developed for measuring the percentage increase in the combined delayed-enhancing area and necrotic area (pD + N) and the percentage increase in the necrotic area (pNI) in the tumor-containing segments pre- and post-TARE. Local progression-free survival (PFS) was compared between patient groups using Cox regression and Kaplan-Meier analyses. Post-TARE HCC with pD + N ≥ 35.5% showed significantly longer PFS than those with pD + N < 35.5% (p = 0.001). The local tumor progression hazard ratio was 17.3 (p = 0.009) for pD + N < 35.5% versus pD + N ≥ 35.5% groups. HCCs with a high pNI tended to have longer PFS, although this difference did not reach statistical significance. HCCs with a larger pD + N are less likely to develop local progression after TARE.

References

Jan 1, 1981·Cancer·A B MillerA Winkler
May 25, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Ching-yee Oliver WongHoward J Dworkin
Sep 6, 2003·International Journal of Radiation Oncology, Biology, Physics·Klaus K HerfarthJürgen Debus
Feb 22, 2007·AJR. American Journal of Roentgenology·Ana L KeppkeFrank H Miller
Feb 22, 2007·AJR. American Journal of Roentgenology·Frank H MillerRiad Salem
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Jan 13, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ahsun RiazRiad Salem
Feb 23, 2010·Seminars in Liver Disease·Riccardo Lencioni, Josep M Llovet
Aug 20, 2010·Radiology·Nicolas D PrionasJohn M Boone
Aug 6, 2011·Journal of Hepatology·Bruno SangroJose I Bilbao
Mar 13, 2013·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Katherine E MaturenJoel F Platt
Mar 19, 2014·Journal of Vascular and Interventional Radiology : JVIR·Caecilia S ReinerHatem Alkadhi
Feb 24, 2016·AJR. American Journal of Roentgenology·Atilla ArslanogluVahid Yaghmai

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Citations

Apr 8, 2020·AJR. American Journal of Roentgenology·Shamar Young, Jafar Golzarian
Nov 26, 2020·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Yeon Hyeon Choe
Jan 23, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Yangsean ChoiBum-Soo Kim
Jun 23, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Riccardo SartorisValérie Vilgrain
Aug 26, 2021·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Seong Ho ParkSeo Young Park
Jan 10, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Neal BhutianiCharles R Scoggins

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Software Mentioned

RECIST
R
R Foundation for Statistical Computing
mRECIST
Matlab

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