Evaluation of effects of long term exposure on lethal toxicity with mammals

Environmental Pollution
Vibha VermaDes W Connell

Abstract

The relationship between exposure time (LT50) and lethal exposure concentration (LC50) has been evaluated over relatively long exposure times using a novel parameter, Normal Life Expectancy (NLT), as a long term toxicity point. The model equation, ln(LT50) = aLC50(ν) + b, where a, b and ν are constants, was evaluated by plotting lnLT50 against LC50 using available toxicity data based on inhalation exposure from 7 species of mammals. With each specific toxicant a single consistent relationship was observed for all mammals with ν always <1. Use of NLT as a long term toxicity point provided a valuable limiting point for long exposure times. With organic compounds, the Kow can be used to calculate the model constants a and v where these are unknown. The model can be used to characterise toxicity to specific mammals and then be extended to estimate toxicity at any exposure time with other mammals.

References

May 25, 2016·Toxicology·Des W ConnellVibha Verma
May 24, 2017·Scientific Reports·Walter W FockeMattheüs Theodor Loots

Citations

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Related Concepts

Genus Saimiri
Organic Chemicals
Mixed breed dog
Toxicity Tests
Uptake
Weighing Patient
House mice
Beagle
Lethal Dose 50
Organism

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