Evaluation of Efficacy and Safety of Latanoprost/Timolol versus Travoprost/Timolol Fixed Combinations for Ocular Hypertension Associated with Uveitis

Ocular Immunology and Inflammation
Masaru TakeuchiYutaka Sakurai

Abstract

To compare latanoprost/timolol (LT) versus travoprost/timolol (TT) fixed combinations for ocular hypertension (OHT) associated with uveitis. Thirty-six patients (55 eyes) who were treated with LT (28 eyes) or TT (27 eyes) for OHT associated with uveitis were reviewed retrospectively. Intraocular pressure (IOP) and inflammation scores at the initiation of treatment and at the last visit during therapy were analyzed. Although IOP was reduced significantly in both LT and TT groups, the reduction rate was significantly greater with TT group than with LT. The differences in the reduction of IOP between the groups remained significant when the cases were classified into inflammation-induced OHT and steroid-induced OHT. Inflammation score was not exacerbated by LT or TT treatment. Both LT and TT are safe and effective for the treatment of OHT associated with uveitis and greater IOP reduction may be achieved by TT than by LT treatment.

References

Feb 15, 1987·American Journal of Ophthalmology·E Bloch-Michel, R B Nussenblatt
Mar 1, 1997·Archives of Ophthalmology·D JohnsonE Lütjen-Drecoll
Mar 1, 1997·Survey of Ophthalmology·R S MoorthyN A Rao
Apr 29, 1998·Journal of the American Optometric Association·I B Gaddie, D W Bennett
Jul 31, 1998·American Journal of Ophthalmology·R D FechtnerR Warwar
Oct 12, 1999·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·J Merayo-LlovesC S Foster
Jan 14, 2000·Acta Ophthalmologica Scandinavica·S L SmithW C Stewart
Jul 6, 2002·Archives of Ophthalmology·Eve J HigginbothamUNKNOWN Fixed Combination Investigative Group
Dec 18, 2002·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Norbert Pfeiffer, UNKNOWN European Latanoprost Fixed Combination Study Group
Jan 22, 2004·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·N A SharifS X Xu
Apr 21, 2004·Journal of Glaucoma·Helen M HerbertSusan L Lightman
Jul 2, 2005·American Journal of Ophthalmology·Howard S BarnebeyMichael V W Bergamini
Oct 1, 2005·American Journal of Ophthalmology·Douglas A JabsUNKNOWN Standardization of Uveitis Nomenclature (SUN) Working Group
Jan 2, 2007·Ophthalmology·Anastasios G P KonstasWilliam C Stewart
Jun 15, 2007·Advances in Therapy·Stephan DunkerUNKNOWN Latanoprost/Timolol Fixed Combination Study Group
Nov 21, 2008·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Kemal OrnekYeliz Turgut
Nov 26, 2008·American Journal of Ophthalmology·Egidio FortunaC Stephen Foster
Feb 3, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Nikos N MarkomichelakisGerasimos Georgopoulos
Oct 1, 2011·Seminars in Ophthalmology·Michael B Horsley, Teresa C Chen
Apr 1, 2014·The British Journal of Ophthalmology·Takayuki KandaMasaru Takeuchi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.