PMID: 19141185Jan 15, 2009Paper

Evaluation of efficacy of thymosin alpha1 in the treatment of sepsis: a systematic review

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
Yang YuPeng Zhang

Abstract

To assess the effects of thymosin alpha1 to enhance immunity and on the prognosis of sepsis. The database from CNKI (1994-2008.10), CBM (1978-2008.10), VIP (1989-2008.10), Wanfang Database (1997-2008.10), PubMed (1966-2008.10), Cochrane Library (Issue 3, 2008), EMBASE(1974-2008.10) and SCI (1974-2008.10) were retrieved using the key words "sepsis OR septicemia OR blood poisoning OR systemic inflammatory response syndrome OR multiple organ failure OR multiple organ dysfunction syndrome" AND "thymosin * OR zadaxin OR thymalfasin". Also related journals were reviewed. Randomized and q-randomized trials of thymosin for sepsis were included. Two investigators were engaged to extract the data independently and evaluate the quality of the included studies with Handbook 4.2.6 recommended standard, and analyzed data with Cochrane Collaboration's RevMan 4.2.10. Five randomized controlled trials (198 patients) were included. Meta-analysis showed that thymosin alpha1 may raise the level of CD4(+)T lymphocytes [WMD=6.24, 95% confidence interval (CI) 1.12 to 11.36] and the ratio of CD4(+)/CD8(+)(WMD=0.14, 95%CI 0.03 to 0.25, P=0.01), improve the immune state of the patients. Also, thymosin alpha1 therapy decreased the score of acute physiolo...Continue Reading

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