Evaluation of eight cephalosporins in hamster colitis model.

Antimicrobial Agents and Chemotherapy
J R EbrightK H Wilson

Abstract

Eight commonly used cephalosporins were evaluated in the hamster colitis mode. They were all found to cause hemorrhagic cecitis and death within 10 days of being given as subcutaneous or oral challenges. Necropsy findings were indistinguishable from clindamycin-induced cecitis. Bacteria-free cecal filtrate obtained from hamsters dying of cephalosporin-induced cecitis contained toxin similar or identical to hat produced by Clostridium difficile isolated from the cecum of a hamster. Daily oral administration of poorly absorbed cephalosporins protected hamsters from clindamycin-induced cecitis and death as long as the cephalosporins were continued. The absorbable cephalosporins were ineffective in protecting hamsters from clindamycin-induced cecitis. This difference probably relates to the lower concentrations of absorbable cephalosporins maintained in the ceca of the hamsters. The possible correlation of these findings to human cases of cephalosporin-induced pseudomembranous colitis is discussed.

References

May 20, 1978·Lancet·H E LarsonS P Borriello
Mar 1, 1977·The Journal of Infectious Diseases·F J Tedesco
Aug 23, 1979·The New England Journal of Medicine·W L GeorgeS M Finegold
Dec 14, 1979·JAMA : the Journal of the American Medical Association·J G BartlettB Lowe
Mar 9, 1978·The New England Journal of Medicine·J G BartlettA B Onderdonk
Apr 1, 1978·The Journal of Infectious Diseases·R H LuskG D Abrams
Apr 1, 1978·The American Journal of Digestive Diseases·D F HutcheonT R Hendrix
Feb 1, 1977·American Journal of Surgery·H J FeeE C Holmes
Aug 23, 1976·JAMA : the Journal of the American Medical Association·J F TuresH D Rose
Apr 1, 1980·Archives of Internal Medicine·S T DontaT D Wilkins
Apr 1, 1980·Infection and Immunity·A B OnderdonkJ G Bartlett
Jun 1, 1980·The Journal of Infectious Diseases·R SaginurJ G Bartlett
Sep 1, 1980·The Journal of Infectious Diseases·H E LarsonS P Borriello

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Citations

May 1, 1982·Antimicrobial Agents and Chemotherapy·R A GreenfieldW A Craig
Oct 1, 1984·Antimicrobial Agents and Chemotherapy·R D Toothaker, G W Elmer
Jun 1, 1985·Antimicrobial Agents and Chemotherapy·R J Boon, A S Beale
Feb 1, 1987·Antimicrobial Agents and Chemotherapy·F LeitnerR E Kessler
Feb 8, 1985·The American Journal of Medicine·R B Sykes, D P Bonner
May 5, 2012·Gut Microbes·Emma L BestMark H Wilcox
Jan 15, 2015·Infectious Disease Clinics of North America·Caroline H Chilton, Jane Freeman
Feb 7, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John G Bartlett
Jan 1, 1987·Infection and Immunity·E L MullerW L George

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