Evaluation of eight different cephalosporins for detection of cephalosporin resistance in Salmonella enterica and Escherichia coli

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
Frank M AarestrupDik Mevius

Abstract

This study evaluates the efficacy of eight different cephalosporins for detection of cephalosporin resistance mediated by extended spectrum beta-lactamases (ESBL) and plasmidic AmpC beta-lactamases in Salmonella and Escherichia coli. A total of 138 E. coli and 86 Salmonella isolates with known beta-lactamase genes were tested for susceptibility toward cefoperazone, cefotaxime, cefpodoxime, cefquinome, ceftazidime, ceftiofur, ceftriaxone, and cefuroxime using minimum inhibitory concentration determinations and disc diffusion. The collection consisted of 84 ampicillin-susceptible, 57 ampicillin-resistant but cephalosporin-susceptible, 56 ESBL isolates and 19 isolates with plasmidic AmpC, as well as 10 ampC hyper-producing E. coli. The minimum inhibitory concentration distributions and zone inhibitions varied with the tested compound. Ampicillin-resistant isolates showed reduced susceptibility to the cephalosporins compared to ampicillin-susceptible isolates. Cefoperazone, cefquinome, and cefuroxime were not useful in detecting isolates with ESBL or plasmidic AmpC. The best substances for detection were cefotaxime, cefpodoxime, and ceftriaxone, whereas ceftazidime and ceftiofur were not as efficient. Ceftriaxone may be the recomme...Continue Reading

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Citations

Aug 13, 2011·The Journal of Antimicrobial Chemotherapy·Eliza BielakHenrik Hasman
Sep 6, 2012·The Journal of Antimicrobial Chemotherapy·Cindy DierikxDik Mevius
Sep 26, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Ashley C CormierPatrick Boerlin
Feb 6, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xiufang LiangJiancheng Zeng
Aug 20, 2021·Journal of Food Protection·Kaknokrat ChonsinOrasa Suthienkul

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