Evaluation of eight enzyme immunoassays for detection of immunoglobulin G against Helicobacter pylori.

Journal of Clinical Microbiology
B C MeijerR J Berrelkamp

Abstract

Eight commercial enzyme-linked immunosorbent assays (ELISAs) were used to test sera taken from 102 patients in whom Helicobacter pylori infection status had been determined by means of biopsy culture, PCR, histology, and urease production and by 13C urea breath test. By those means, 61 patients had been found to be infected. Assays were compared by receiver operating characteristic analysis. Sensitivities ranged from 86 to 98%; specificities ranged from 83 to 98%. In a group consisting of the assays by Bio-Whittaker, Meddens Biotech, Orion (Pyloriset EIA G, new version), and Enteric Products, Inc. (HM Cap), differences in performance were not statistically significant. Sensitivities in this group ranged from 93 to 98%; specificities ranged from 95 to 98%. Assays from this group may be useful in addition to biopsy-based methods in diagnosing H. pylori infection.

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Citations

Nov 18, 2003·Helicobacter·Hilpi RautelinFrancis Mégraud
Apr 28, 2005·International Journal of Clinical Practice·M SönmezogluS G Barut
Dec 22, 2004·Helicobacter·Hwai-Jeng LinYueh-Hsing Ou
Feb 13, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·S Sasidharan, A M Uyub
Nov 17, 2010·Archives of Gynecology and Obstetrics·Ghada M Mansour, Ehab H Nashaat
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Nov 24, 1999·Journal of Clinical Pathology·C A McNulty, J I Wyatt
May 18, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Akbar KhalilpourRahmah Noordin
Sep 26, 2012·BMC Gastroenterology·Harald E VonkemanBac Dijkmans
Apr 17, 2016·Applied Microbiology and Biotechnology·Akbar KhalilpourAli Khademhosseini
May 8, 2001·European Journal of Gastroenterology & Hepatology·N L ArentsJ H Kleibeuker
Aug 18, 2005·Journal of Gastroenterology and Hepatology·Zhigang RenRobert Clancy
Feb 5, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H T J I de LeestY J Debets-Ossenkopp
Dec 4, 2001·Journal of Immunological Methods·M UttT Wadström
Sep 17, 1998·Journal of Clinical Microbiology·R J LaheijA L Verbeek

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