Evaluation of electrocardiographic and hemodynamic effects of caffeine with acute dosing in healthy volunteers

Pharmacotherapy
R AmmarC M White

Abstract

To evaluate the effects of moderate, single-dose caffeine consumption on electrocardiographic variables: PR, QRS, QT, QTc, and RR intervals, and QT and QTc interval dispersion. Effects of caffeine on blood pressure and heart rate also were evaluated. Randomized, double-blind, placebo-controlled, crossover study. University school of pharmacy. Ten healthy volunteers aged 17 years or older. Participants abstained from caffeinated products for at least 2 days before the study began and were randomly designated to receive placebo or caffeine 400 mg on various days. For each of the study phases, a baseline 12-lead electrocardiogram (ECG) was performed and a subsequent 12-lead ECG performed 3 hours after ingesting the study drug. Blood pressure readings were taken with each ECG. No significant changes in any intragroup or intergroup electrocardiographic variables occurred. Caffeine increased blood pressure (systolic blood pressure [SBP]/diastolic blood pressure [DBP]) from 118+/-5/75+/-6 mm Hg to 128+/-8/77+/-7 mm Hg versus baseline (p=0.0022 and p=0.0368 for SBP and DBP, respectively). After drug dosing, SBP in the caffeine group was significantly higher than in the placebo group (128+/-8 mm Hg versus 119+/-7 mm Hg, p=0.0174). Moder...Continue Reading

References

Aug 1, 1975·Journal of Molecular and Cellular Cardiology·M J Hughes, I A Coret
Jan 26, 1978·The New England Journal of Medicine·D RobertsonJ A Oates
Apr 1, 1990·The American Journal of Cardiology·B H SungM F Wilson
Dec 1, 1985·The American Journal of Cardiology·P SmitsA van't Laar
Mar 15, 1984·The American Journal of Cardiology·T L WhitsettH D Christensen
Apr 7, 1983·The New England Journal of Medicine·D J DobmeyerS F Schaal
Apr 1, 1981·The Journal of Clinical Investigation·D RobertsonJ A Oates
Nov 14, 1997·The American Journal of Cardiology·S H Hohnloser
Mar 17, 1999·Journal of Toxicology. Clinical Toxicology·O Strubelt, K W Diederich
May 25, 1999·Internal Medicine·T AizakiT Izumi

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Citations

Sep 17, 2005·Neurourology and Urodynamics·Erin T BirdK Scott Coffield
Nov 28, 2012·Clinical Drug Investigation·Manuel Martínez-SellésFrancisco Fernández-Avilés
Oct 7, 2011·Pediatric Emergency Care·Govinda PaudelJayendra Sharma
Feb 4, 2011·Nutrition Journal·Silvio BuscemiSalvatore Verga
Dec 29, 2015·The American Journal of Cardiology·Sachin A ShahCarolyn S Lacey
Mar 26, 2011·The American Journal of Medicine·Daniel J Pelchovitz, Jeffrey J Goldberger
Mar 5, 2016·Clinical Physiology and Functional Imaging·R Matthew BrothersPaul S Bhella
Sep 1, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E Mark HaackeJaladhar Neelavalli
Jul 16, 2011·The British Journal of Surgery·R AggarwalA Darzi
Oct 10, 2002·The American Journal of Cardiology·Hugo P SondermeijerHenry Krum
Jan 23, 2014·International Journal of Cardiology·Sachin A ShahIan C Riddock
Jun 18, 2016·European Journal of Nutrition·Andrés GarcíaJulio Sánchez
Oct 10, 2014·European Journal of Preventive Cardiology·Kanokwan BunsawatTracy Baynard
Jun 25, 2016·The Annals of Pharmacotherapy·Sachin A ShahAnthony E Dargush
Apr 28, 2017·Journal of the American Heart Association·Emily A FletcherSachin A Shah
Jul 21, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Bokyung MinC Michael White
May 30, 2019·Journal of the American Heart Association·Sachin A ShahSanjay Kaul
Oct 6, 2015·Research in Cardiovascular Medicine·Siyavash JoukarSoodabe Ghorbani Shahrbabaki

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