Evaluation of embryo-fetal development in rats housed in concrete or hwangto cages during pregnancy

Birth Defects Research. Part B, Developmental and Reproductive Toxicology
J C LeeJong-Choon Kim

Abstract

Recently, it was reported that the 4-week exposure of rats to a concrete building environment under cool temperatures (11.7-12.1 degrees C) had adverse effects on the general health parameters. This study examined the potential effects of concrete and hwangto building environments on pregnant dams and embryo-fetal development in Sprague-Dawley rats. Groups of 10 mated females were exposed to polycarbonate (control), concrete, or hwangto cages from gestational days (GD) 0 to 20 under cool temperatures (11.9-12.5 degrees C). All the females underwent a caesarean section on GD 20, and their fetuses were examined for any morphological abnormalities. The temperatures in the cages were similar in all groups but the relative humidity in the concrete and hwangto groups were higher than in the control group. The concentration of volatile organic compounds in the hwangto group during the study period was lower than in the control group. In the concrete group, maternal effects manifested as an increase in the incidence of clinical signs, a lower body weight, and a decrease in the thymus and ovary weights. Developmental effects included increased post-implantation loss and decreased litter size. In contrast, in the hwangto group, there wer...Continue Reading

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Citations

Mar 6, 2013·Primary Care Respiratory Journal : Journal of the General Practice Airways Group·Ulugbek NurmatovAziz Sheikh
Mar 3, 2015·European Respiratory Review : an Official Journal of the European Respiratory Society·Ulugbek B NurmatovAziz Sheikh

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