Evaluation of estimates of alveolar gas exchange by using a tidally ventilated nonhomogenous lung model

Journal of Applied Physiology
Thierry Busso, P A Robbins

Abstract

The purpose of this study was to evaluate algorithms for estimating O2 and CO2 transfer at the pulmonary capillaries by use of a nine-compartment tidally ventilated lung model that incorporated inhomogeneities in ventilation-to-volume and ventilation-to-perfusion ratios. Breath-to-breath O2 and CO2 exchange at the capillary level and at the mouth were simulated by using realistic cyclical breathing patterns to drive the model, derived from 40-min recordings in six resting subjects. The SD of the breath-by-breath gas exchange at the mouth around the value at the pulmonary capillaries was 59.7 +/- 25.5% for O2 and 22.3 +/- 10.4% for CO2. Algorithms including corrections for changes in alveolar volume and for changes in alveolar gas composition improved the estimates of pulmonary exchange, reducing the SD to 20.8 +/- 10.4% for O2 and 15.2 +/- 5.8% for CO2. The remaining imprecision of the estimates arose almost entirely from using end-tidal measurements to estimate the breath-to-breath changes in end-expiratory alveolar gas concentration. The results led us to suggest an alternative method that does not use changes in end-tidal partial pressures as explicit estimates of the changes in alveolar gas concentration. The proposed metho...Continue Reading

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Citations

Mar 3, 2010·European Journal of Applied Physiology·Carlo CapelliSilvia Pogliaghi
Apr 22, 2015·European Journal of Applied Physiology·V Cettolo, Maria Pia Francescato
Jun 13, 2014·European Journal of Applied Physiology·Aurélien BringardGuido Ferretti
Mar 17, 2018·European Journal of Applied Physiology·Valentina Cettolo, Maria Pia Francescato
Jun 26, 2018·European Journal of Applied Physiology·Petra GoljaMaria Pia Francescato
Jun 3, 2017·Clinical Physiology and Functional Imaging·Valentina Cettolo, Maria Pia Francescato
Dec 6, 2018·European Journal of Applied Physiology·Maria Pia Francescato, Valentina Cettolo
May 8, 2018·European Journal of Applied Physiology·Susan A Ward
Jul 22, 2014·Theoretical Biology & Medical Modelling·David A ShelleyLaurel J Ng
Oct 5, 2019·Experimental Physiology·Jessica KoschateMaria Pia Francescato

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