Evaluation of exercise capacity with cardiopulmonary exercise testing and type B natriuretic peptide concentrations in adult patients with patent atrial septal defect

Cardiology
Olga TrojnarskaAndrzej Cieśliński

Abstract

Adults with patent atrial septal defect (ASD) usually find their exercise capacity satisfactory, and therefore hesitate to accept proposed surgical treatment of the heart disease. The aim of our study was to evaluate both the exercise capacity, using the cardio-pulmonary stress test, and brain natriuretic peptide (BNP) levels in asymptomatic adults with ASD. Thirty-six patients with patent secundum type ASD (aged mean 44.7 +/- 8.2 years) were studied. The control group consisted of 25 healthy subjects at the mean age of 45.6 +/- 6.1 years. Echocardiography and CPST were performed and BNP levels measured in all subjects. Oxygen uptake (VO2 max) was lower in ASD patients than in controls (22.1 +/- 5.6 vs. 30.0 +/- 6.8 ml/kg/min, p = 0.00001); the VE/VO2 slope was elevated in ASD patients compared with healthy subjects (31.3 +/- 6.6 vs. 26.9 +/- 3.3, p = 0.001), and exceeded 34 in 5 patients. VO2 max showed a negative correlation with the pulmonary to systemic flow ratio Qp:Qs (r = -0.46, p = 0.004), and a positive correlation was found between the VE/VO2 slope and Qp:Qs (r = 0.32, p = 0.05). BNP levels were higher in the ASD group than in the controls (60.6 +/- 49.9 vs. 32.6 +/- 24.5 pg/ml, p = 0.02). BNP correlated positively wi...Continue Reading

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Citations

Sep 22, 2012·Cardiology in the Young·Jannet A EindhovenJolien W Roos-Hesselink
Dec 12, 2012·Biomarkers in Medicine·Amiram NirAzaria Jjt Rein
Oct 1, 2011·International Journal of Cardiology·Anthony J BarronIqbal Malik
Dec 15, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Alexander Van De BruaeneWerner Budts
Jun 9, 2017·Scandinavian Cardiovascular Journal : SCJ·Johan HeibergVibeke E Hjortdal
Apr 5, 2017·Annals of the American Thoracic Society·Valentina MantegazzaAlfred Hager
May 16, 2017·Scandinavian Cardiovascular Journal : SCJ·Johan HeibergVibeke E Hjortdal

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