Evaluation of expression of vitamin D receptor related lncRNAs in lung cancer

Non-coding RNA Research
Tahereh GhelijiSoudeh Ghafouri-Fard

Abstract

Lung cancer as the most common cancer in the world is associated with high rate of mortality. Previous studies have detected expression of vitamin D receptor (VDR) in lung cancer tissues and reported significant of this gene in determination of patients' survival. Methods: In the current study, we assessed expression of VDR and five long non-coding RNAs (lncRNAs) which have been associated with VDR (MALAT1, SNHG16, SNHG6, LINC00346, LINC00511) in 32 pairs of lung cancer tissues and adjacent non-cancerous tissues (ANCTs) using real time PCR method. Expression of VDR was significantly decreased in tumor tissues obtained from male patients compared with their matched ANCTs (ER = 0.31, P value = 0.02). However, this pattern was not detected in female subjects (ER = 0.93, P value = 0.94). Expression of LINC00346 was significantly decreased in tumoral tissues compared with ANCTs (Expression ratio (ER) = 0.38, P value = 0.03). When evaluating expression of this lncRNA based on the sex of patients, differences in its expression was only significant among males (ER = 0.3, P value = 0.04). VDR expression was significantly associated with sex of patients in a way that most male patients exhibited down-regulation of this gene in their tumo...Continue Reading

Citations

Nov 24, 2020·Nutrition and Cancer·Weijie WangWei Zuo
May 21, 2021·Molecular and Cellular Endocrinology·Daniel D Bikle
Jun 21, 2021·BMC Infectious Diseases·Mohammad TaheriSoudeh Ghafouri-Fard

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