Evaluation of extracellular adenine nucleotides hydrolysis in platelets and biomarkers of oxidative stress in Down syndrome individuals

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Maurício FerreiraRosélia Maria Spanevello

Abstract

Down syndrome (DS) is caused by the triplication of chromosome 21. Studies have demonstrated platelets abnormalities and oxidative stress in DS subjects. The enzymes NTPDase, 5'-nucleotidase and adenosine deaminase (ADA) represent an important therapeutic target since they interfere in the extracellular nucleotide pool altering platelet functions. In this study, we evaluated the ectonucleotidases activities and oxidative stress parameters in samples of DS and healthy individuals. The population consisted of 28 subjects with DS and 28 healthy subjects as a control group. Blood was obtained from each subject and used for platelet and serum preparation. NTPDase activity using ATP as substrate was increased in platelets of DS patients in relation to the control group; however, no alterations were observed in the ADP hydrolysis. A decrease in the 5'-nucleotidase activity and an increase in the ADA activity was observed in platelet of DS subjects when compared to healthy individuals (P<0.05). The lipid peroxidation and total thiol content was decreased in serum of DS individuals. Furthermore, superoxide dismutase and catalase activities were increased in whole blood of this group (P<0.05). Alterations in the ectonucleotidase activiti...Continue Reading

References

Oct 1, 1988·Journal of Geriatric Psychiatry and Neurology·G S Zubenko, R Howland
Jan 1, 1994·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·J PrinceL Oreland
Dec 31, 1998·Free Radical Biology & Medicine·S V JovanovicK MacLeod
Jun 8, 2001·American Journal of Human Genetics·M PogribnaS J James
May 22, 2003·Neuroscience Letters·Barbara BegniCarlo Ferrarese
Jan 27, 2005·Life Sciences·Santosh Sinha
May 24, 2006·Free Radical Biology & Medicine·Kok Seong LimBarry Halliwell
Sep 7, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·David WebbParesh Vyas
Nov 6, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Andre StrydomZuzana Walker
Feb 21, 2009·Journal of Intellectual Disability Research : JIDR·J C VisB J M Mulder
Jul 25, 2009·Journal of Neurology·Roselia Maria SpanevelloMaria Rosa Chitolina Schetinger
Sep 30, 2009·Clinical Biochemistry·Carlos CamposAngela Casado
Jan 26, 2010·Pediatric Research·Ruud H J VerstegenEsther DE Vries
Nov 25, 2011·European Journal of Pediatrics·Annelyse Bruwier, Christophe F Chantrain
Jan 17, 2012·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Daniela ZaniniMaria Rosa Chitolina Schetinger
Jun 9, 2012·Indian Journal of Pediatrics·S Mehar SulthanaK Ramachandra Rao
Sep 25, 2012·European Journal of Pharmacology·Patrick Mathieu
Feb 22, 2013·Circulation·Sanjana DayalSteven R Lentz
Sep 6, 2013·Life Sciences·Thais Regina GarletDanilo Wilhelm Filho
Jan 10, 2014·Thrombosis and Haemostasis·Francesco Violi, Pasquale Pignatelli
Feb 15, 2014·World Journal of Cardiology·Joel Hernandez, Raul Moreno
Mar 19, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Rodrigo RodriguesRoselia Spanevello
Sep 17, 2014·Journal of Thrombosis and Haemostasis : JTH·J M HerterA Zarbock

❮ Previous
Next ❯

Citations

Jul 15, 2021·Disease Markers·Dominik SzwajgierWioletta Żukiewicz-Sobczak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Javed AnwarMaria R C Schetinger
© 2021 Meta ULC. All rights reserved