Evaluation of factor V Leiden, prothrombin and methylenetetrahydrofolate reductase gene mutations in patients with severe pregnancy complications in northern Finland

Gynecologic and Obstetric Investigation
J JarvenpaaM Ryynanen

Abstract

Thrombosis in placenta may lead to severe pregnancy complications. Most important inherited thrombophilias are factor V Leiden mutation, prothrombin mutation, and methylenetetrahydrofolate reductase mutation. The aim of our research was to evaluate the prevalence of inherited thrombophilias in severe pregnancy complications and in normal pregnancies. The study subjects with severe preeclampsia, intrauterine growth restriction, placental abruption or fetal death were collected during the period 1999-2004 from Oulu University Hospital. We also collected during the same period voluntary parturients with normal pregnancy outcome as the control group. FVL, FII, and MTHFR gene mutations of the patients and controls were analyzed. We found a significant difference in the prevalence of FVL mutation between the groups. There were 9.5% FVL mutations in the study group compared to 1.8% in the control group; the observed difference between prevalences was 7.7% (95% CI 2.0-13.4). No statistical difference was found in the FII or MTHFR mutations between the groups. All FV and FII mutations were heterozygous and all the MTHFR mutations homozygous. Women with thrombophilia have a risk for severe pregnancy complications. Randomized controlled t...Continue Reading

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Citations

Dec 30, 2009·Journal of Thrombosis and Thrombolysis·Agnieszka Seremak-MrozikiewiczPrzemyslaw M Mrozikiewicz
Nov 10, 2011·Journal of Thrombosis and Thrombolysis·Shohreh Malek-KhosraviAbbas Parsian
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Jan 11, 2008·Journal of Perinatal Medicine·Sabine MützeWerner Rath
Jun 28, 2014·Lipids in Health and Disease·Ning-Yuan ChenShang-Ling Pan
Apr 4, 2007·American Journal of Obstetrics and Gynecology·Meghana ToalJohn C P Kingdom
Oct 11, 2016·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Erin M HemsworthUNKNOWN Knowledge Synthesis Group on Determinants of Preterm/LBW Births
Feb 16, 2008·Epidemiology·Nikos Zdoukopoulos, Elias Zintzaras
May 23, 2009·Obstetrics and Gynecology·Francesca FaccoWilliam Grobman
May 1, 2019·The Journal of Obstetrics and Gynaecology Research·Yuan Li, Yan Ruan

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