Evaluation of faecal occult blood test and lactoferrin latex agglutination test in screening hospitalized patients for diagnosing inflammatory and non-inflammatory diarrhoea in Dhaka, Bangladesh

Digestion
Hasan AshrafNiklaus Gyr

Abstract

Inflammatory diarrhoea (ID) resulting from Shigella, Salmonella, Campylobacter and Entamoeba histolytica requires specific diagnosis for therapy. Differentiation between ID and non-inflammatory diarrhoea (NID) is often not clinically possible. A faecal occult blood test (FOBT) correlates with faecal leucocytes. Lactoferrin indicates an inflammatory process as a marker for faecal leucocytes. We evaluated diagnostic values of lactoferrin latex agglutination test (LT) either alone or in combination with FOBT, correlating with stool microscopy and microbiology in differentiating ID from NID. The study population constituted patients enrolled in 2% systematic sampling of patients under Diarrhoeal Disease Surveillance System of Dhaka Hospital, ICDDR,B. Between July and November 2002, 594 patients were enrolled; evaluation of FOBT and LT were done in 448/594 (75%) patients from whom either a single enteropathogen (315/594, 53%) or no pathogen (133/594, 22%) were identified and 146 were excluded for multiple pathogens. Invasive and non-invasive pathogens were isolated from 24% and 76% of the patients. FOBT and LT were positive in 40% and 39% of the samples. The sensitivities, specificities, PPVs, NPVs, and accuracies of FOBT were 55, 6...Continue Reading

References

May 1, 1992·Journal of Clinical Microbiology·R L GuerrantA G Lee
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·P SpeelmanT Butler
Jun 28, 1985·The American Journal of Medicine·R L GuerrantD H Gröschel
Jun 25, 1983·British Medical Journal·B J StollM Ahmed
Oct 23, 1982·British Medical Journal·B J StollH Banu
Dec 12, 1994·Archives of Internal Medicine·J R MillerR L Guerrant
Jun 1, 1996·The Pediatric Infectious Disease Journal·L HuichoR L Guerrant
Apr 1, 1996·Journal of Clinical Microbiology·S W ChoiR L Guerrant
Jul 1, 1997·The Pediatric Infectious Disease Journal·L HuichoR L Guerrant
Jun 1, 1994·Journal of Travel Medicine·E G ScerpellaC D Ericsson
May 1, 1999·The Pediatric Infectious Disease Journal·J G Ruiz-Peláez, S Mattar
Apr 17, 2001·The American Journal of Tropical Medicine and Hygiene·A R BouckenoogheR Steffen
Aug 29, 2001·Pathology·C J McIverW D Rawlinson
Mar 1, 2003·Paediatric Drugs·Nure H Alam, Hasan Ashraf
Jul 29, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christopher J GillDavidson H Hamer
Aug 29, 2006·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Jessmi M L Ling, Anthony B Schryvers

❮ Previous
Next ❯

Citations

Dec 24, 2008·Analytical and Bioanalytical Chemistry·Albrecht Pfäfflin, Erwin Schleicher
Aug 5, 2009·Internal Medicine·Tetsuo HayakawaHiroshi Ishiguro
Jul 5, 2013·Clinical Microbiology Reviews·Carey-Ann D Burnham, Karen C Carroll
Oct 24, 2009·Internal Medicine Journal·D R van LangenbergP R Gibson
Jul 21, 2012·Journal of Clinical Pathology·Roy A Sherwood
Oct 18, 2020·Gastroenterology·Yael R Nobel, Daniel E Freedberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amoebiasis

Amoebiasis, infection by the protozoan parasite Entamoeba histolytica, remains a global health problem, despite the availability of effective treatment. Here is the latest research.

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.

Related Papers

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
R J C SteeleC G Fraser
International Journal for Quality in Health Care : Journal of the International Society for Quality in Health Care
H NakamaB Zhang
Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
A GillbergL I Olsson
© 2021 Meta ULC. All rights reserved