Evaluation of Fall and Fracture Risk Among Men With Prostate Cancer Treated With Androgen Receptor Inhibitors: A Systematic Review and Meta-analysis.

JAMA Network Open
Zin W MyintJill M Kolesar

Abstract

A high incidence of fall and fracture in a subset of patients treated with androgen receptor inhibitors (ARIs) has been reported, although the relative risk (RR) of fall and fracture for patients who receive ARI treatment is unknown. To evaluate whether treatment with ARIs is associated with an elevated relative risk for fall and fracture in patients with prostate cancer. Cochrane, Scopus, and MedlinePlus databases were searched from inception through August 2019. Randomized clinical trials comparing patients with prostate cancer treated with any ARI or placebo were included. Two independent reviewers used a standardized data extraction and quality assessment form. A mixed effects model was used to estimate the effects of ARI on relative risk, with included studies treated as random effects and study groups treated as fixed effects in the pooled analysis. Sample size for each study was used to weight the mixed model. Statistical analysis was performed from August to October 2019. The primary outcome was RR of fall and fractures for patients receiving ARI treatment. Eleven studies met this study's inclusion criteria. The total population was 11 382 men (median [range] age: 72 [43-97] years), with 6536 in the ARI group and 4846 i...Continue Reading

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Citations

Mar 10, 2021·Expert Review of Clinical Pharmacology·Valeria Emma PalmieriRoberta Giorgione

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Methods Mentioned

BETA
xenograft

Software Mentioned

MedlinePlus
SAS
Scopus
AFFIRM

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