Evaluation of fatty acid/alcohol-based hydrophobic deep eutectic solvents as media for extracting antibiotics from environmental water

Analytical and Bioanalytical Chemistry
Weiyang TangKyung Ho Row

Abstract

Fatty acid/alcohol-based hydrophobic deep eutectic solvents (DESs) have been considered to be eco-friendly alternatives to replace conventional hydrophobic organic solvents (i.e., halogenated solvents). These novel eco-friendly solvents are applied in the extraction and determination of two antibiotics (levofloxacin, LOF; ciprofloxacin, COF) in environmental water by liquid-liquid microextraction (LLME). Two different families of hydrophobic DESs, one based on fatty acids and the other on fatty alcohols, were prepared and applied as a microextraction solvent. The study results showed that 1-octanol/ tricaprylylmethylammonium chloride-based DES (DES-14) had the best extraction efficiency. The vortex-assisted method exhibited better extraction efficiency than the heating, ultrasound, and microwave auxiliary methods in LLME. The main factors affecting the vortex-assisted LLME were optimized statistically using the Box-Behnken design (BBD) combined with response surface methodology (RSM). The optimal conditions for LOF and COF were as follows: 14:174 μL DES, 5.7 min vortex-assisted time, and 8.7% NaCl, w/v. Under these conditions, hydrophobic DES-based LLME was established for extraction and determination LOF and COF from environme...Continue Reading

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Citations

Aug 20, 2019·Water Environment Research : a Research Publication of the Water Environment Federation·Daniel D SnowJonathan Brett Sallach
Jan 14, 2020·Analytical and Bioanalytical Chemistry·Zélie TriauxChristophe Marcic
Dec 9, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jennifer A KistGary A Baker
Dec 18, 2020·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Shaomin MaMing Guo
Nov 2, 2021·The Journal of Physical Chemistry. B·Hirad S SalehiThijs J H Vlugt

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