Evaluation of feasibility of mutagenic testing of shale oil products and effluents

Environmental Health Perspectives
J L EplerM R Guerin

Abstract

In an effort to gather preliminary information on the potential genetic hazards of proposed or existing oil shale technologies, we have begun a correlated analytical and genetic analysis of a number of test materials. The work is divided into two phases: one deals with known compounds expected to occur in the environment through shale oil production or use; the other deals with actual samples from existing or experimental processes. A fractionation procedure has been applied to crude product and aqueous product material from an oil shale process. Mutagenicity of the various fractions was assayed by using reversion of histidine-requiring auxotrophs of Salmonella typhimurium (strain TA100, base-substitution mutant; TA98 and TA1537, frameshift mutants). In order to incorporate metabolic activation of these fractions and compounds, we used liver homogenates (S-9) from rats induced with Aroclor 1254 in the standard plate assay. Preliminary results implicate chemical constituents of these fractions (identified or predicted) were tested individually for their mutagenic activity and correlated with the genetic monitoring.

References

Feb 14, 1975·Science
Dec 1, 1976·Environmental Research·I B Rubin, M R Guerin
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Feb 1, 1976·Mutation Research·F J De Serres
Feb 1, 1969·Analytical Chemistry·J H BellA W Spears

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Citations

Dec 6, 2014·Mutation Research. Reviews in Mutation Research·Larry D Claxton
Jul 1, 1983·Mutation Research·C Y MaJ L Epler
May 1, 1981·Mutation Research·E J LavoieD Hoffmann
Apr 1, 1985·Mutation Research·Z Matijasević, E Zeiger
Nov 1, 1981·Journal of Toxicology and Environmental Health·J A Ellenton, D J Hallett

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