PMID: 10838209Jun 6, 2000Paper

Evaluation of fecal mutagenicity and colorectal cancer risk

Mutation Research
Theo M C M de Kok, J M van Maanen

Abstract

Colorectal cancer is one of the most common internal malignancies in Western society. The cause of this disease appears to be multifactorial and involves genetic as well as environmental aspects. The human colon is continuously exposed to a complex mixture of compounds, which is either of direct dietary origin or the result of digestive, microbial and excretory processes. In order to establish the mutagenic burden of the colorectal mucosa, analysis of specific compounds in feces is usually preferred. Alternatively, the mutagenic potency of fecal extracts has been determined, but the interpretation of these more integrative measurements is hampered by methodological shortcomings. In this review, we focus on exposure of the large bowel to five different classes of fecal mutagens that have previously been related to colorectal cancer risk. These include heterocyclic aromatic amines (HCA) and polycyclic aromatic hydrocarbons (PAH), two exogenous factors that are predominantly ingested as pyrolysis products present in food and (partially) excreted in the feces. Additionally, we discuss N-nitroso-compounds, fecapentaenes and bile acids, all fecal constituents (mainly) of endogenous origin. The mutagenic and carcinogenic potency of th...Continue Reading

References

Sep 1, 1978·Steroids·I A MacdonaldC E Meier
Oct 1, 1979·Digestive Diseases and Sciences·M MoskovitzM H Floch
Oct 1, 1979·Food and Cosmetics Toxicology·C L WaltersR Walker
Nov 1, 1978·The Analyst·C L WaltersP L Smith
Aug 1, 1976·Lipids·J F SperryT D Wilkins
Sep 16, 1992·Journal of Chromatography·T M de KokJ C Kleinjans
Oct 30, 1992·Journal of Chromatography·M G KnizeG A Gross
Jan 1, 1992·Critical Reviews in Biochemistry and Molecular Biology·S Tsuchida, K Sato
Nov 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K B ShapiroD A Roe
Sep 3, 1991·Biochemistry·P ZimniakR Lester
Oct 1, 1991·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·R Van der MeerJ A Lapré
Jun 1, 1991·Mutation Research·P P NairA Schatzkin
Apr 1, 1991·International Journal of Cancer. Journal International Du Cancer·H BoeingM Meinhardt
Apr 1, 1991·Carcinogenesis·A M ShamsuddinE Hale
Mar 1, 1991·Mutation Research·A C PoveyC C Harris

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Citations

May 19, 2009·European Journal of Nutrition·Adriana Nowak, Zdzislawa Libudzisz
Feb 12, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qingchao ZhuHuanlong Qin
Aug 17, 2001·Mutation Research·P R DebruyneM M Mareel
Apr 26, 2003·Mutation Research·Anja SchaeferhenrichBeatrice Louise Pool-Zobel
Mar 28, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A SchaeferhenrichB L Pool-Zobel
Aug 6, 2002·Mutation Research·Michael GleiBeatrice L Pool-Zobel
Feb 8, 2008·The British Journal of Nutrition·Kerstin SchnäbeleGerhard Rechkemmer
May 10, 2005·The British Journal of Nutrition·Beatrice L Pool-Zobel
Feb 3, 2012·Biological Reviews of the Cambridge Philosophical Society·Annemarie Boleij, Harold Tjalsma
Aug 5, 2010·Environmental Health Perspectives·Larry D ClaxtonDavid M DeMarini
Jan 1, 2005·Environmental Health Perspectives·Tom Van de WieleSteven Siciliano
Aug 22, 2001·Reviews on Environmental Health·I T Vermeer, J M van Maanen
Jul 14, 2012·Journal of Toxicology and Environmental Health. Part a·Sofia AugustoCristina Branquinho
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·A BardelliC Lengauer
Aug 26, 2009·Nutrition Reviews·Jennifer R PearsonIan R Rowland
Feb 18, 2015·Drug Metabolism Reviews·Jolantha BeyerleCornelia M Ulrich
Jun 17, 2004·Environmental and Molecular Mutagenesis·Amanda J Cross, Rashmi Sinha
May 5, 2004·Best Practice & Research. Clinical Gastroenterology·Patricia M Heavey, Ian R Rowland
Jul 6, 2014·Molecular Nutrition & Food Research·Juana I MoseleMaría-José Motilva
Jul 15, 2015·Nutrition Research Reviews·Kristin A VerbekeKieran M Tuohy
May 16, 2015·Critical Reviews in Food Science and Nutrition·Daniel DemeyerMichèle Ulens
Dec 4, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Erba DanielaCasiraghi M Cristina
Jul 11, 2014·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Adriana NowakZdzisława Libudzisz
May 14, 2009·Expert Review of Molecular Diagnostics·Jean-François BrugèrePierre Peyret
Sep 19, 2002·Nutrition and Cancer·Julie A WoodsNora M O'Brien
Dec 15, 2005·Nutrition and Cancer·Yuqing Yang, Daniel D Gallaher
Oct 30, 2004·International Journal of Toxicology·Aramandla RameshEric H Weyand
Aug 4, 2005·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·M GleiB L Pool-Zobel
Jul 20, 2014·Carcinogenesis·James J GoedertRashmi Sinha

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