Evaluation of fecal myeloperoxidase as a biomarker of disease activity and severity in ulcerative colitis.

Digestive Diseases and Sciences
Ibrahim MasoodiKartar Singh

Abstract

Subclinical inflammation in ulcerative colitis (UC) can predispose to relapses and biomarkers can detect mucosal inflammation. To study the role of fecal myeloperoxidase (FMPO) in assessing disease activity and response to therapy in UC. Patients with UC attending our hospital from July 2005 to September 2006 were studied. All patients underwent clinical, endoscopic, and histological assessment for disease extent and severity. Estimation of FMPO levels at baseline and on follow-up was carried out. Age-matched healthy controls were studied for FMPO levels. A total of 55 patients of UC (30 males, 25 females, mean age 38.6 ± 12 years) and 54 age-matched controls (mean age 37.6 ± 13.6 years) were studied. Cases had higher median MPO levels than controls (0.42 [IQR 0.84] vs. 0.06 [IQR 0.12]); (p < 0.001). Cases with endoscopically more severe disease (Gr III & IV; n = 18) had higher median FMPO levels compared to those with milder disease (Gr II, n = 37), [0.075 (IQR 1.315) vs. 0.315 (IQR 0.813); p = 0.02]. The median MPO level in 27 patients was 0.58 [IQR 0.89] units/ml at presentation which on follow-up decreased significantly to 0.18 [IQR 0.42] units/ml (p value 0.002). However, there was no significant association between FMPO a...Continue Reading

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Citations

Feb 5, 2014·Biochemistry. Biokhimii︠a︡·O M PanasenkoA V Sokolov
Jul 15, 2016·Biomarkers in Medicine·Barbara Lisowska-MyjakEwa Skarżyńska
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Jul 3, 2019·Molecular & Cellular Proteomics : MCP·Hao Q TranAndrew T Gewirtz
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Mar 7, 2020·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Xu ZhangQiu Chen
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Sep 1, 2019·Molecular & Cellular Proteomics : MCP·Hao Q TranAndrew T Gewirtz
Jan 30, 2021·Food Research International·Roberto de Paula do NascimentoMário Roberto Maróstica Junior
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May 1, 2021·International Journal of Molecular Sciences·Ewa ŻyłaJoanna Gromadzka-Ostrowska
Aug 8, 2021·Journal of Clinical Medicine·Jared MatsonNicole E Lopez

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