Evaluation of feline oral squamous cell carcinomas for p16CDKN2A protein immunoreactivity and the presence of papillomaviral DNA

Research in Veterinary Science
J S MundayA F French

Abstract

Oral squamous cell carcinomas (OSCCs) develop commonly in cats. While the cause of the feline neoplasms is unknown, a quarter of human OSCCs are caused by papillomavirus (PV) infection. As PV DNA has been previously detected in a feline OSCC, it was hypothesised that PV infection could be a significant cause of feline OSCCs. Human OSCCs that are caused by PVs contain increased p16(CDKN2A) protein (p16), which can be detected using immunohistochemistry. In cats, increased p16 immunoreactivity has been reported within PV-associated skin lesions. This study evaluated p16 immunoreactivity within 30 feline OSCCs. Additionally, PCR was used to amplify PV DNA from the OSCCs. Increased p16 immunoreactivity was present within 2 OSCCs. However, as PV DNA was not amplified from any OSCC in this study, it cannot be confirmed that the increased p16 was caused by PV infection. Therefore, these results do not support the hypothesis that PVs are a significant cause of OSCCs in cats. Loss of p16 expression is considered an important process in the development of human non-PV-induced OSCCs. In contrast, loss of p16 immunoreactivity was only present in 2 feline OSCCs. This suggests that human and feline OSCCs develop due to different molecular me...Continue Reading

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Citations

Aug 24, 2013·Pathology Research International·Jackie M Wypij
Jan 25, 2014·The Veterinary Journal·John S Munday
Jul 20, 2011·BMC Veterinary Research·Katherine MitsourasKristopher Jl Irizarry
Mar 12, 2016·The Veterinary Journal·Wachiraphan SupsavhadThomas J Rosol
Mar 22, 2015·Research in Veterinary Science·John S Munday, Adrienne F French
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Aug 18, 2016·Veterinary Sciences·Wachiraphan SupsavhadThomas J Rosol
Sep 11, 2019·Animals : an Open Access Journal From MDPI·John S MundayDanielle Aberdein
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Jun 18, 2021·The Journal of Veterinary Medical Science·Nanako Yamashita-KawanishiTakeshi Haga
Aug 29, 2021·Viruses·John S Munday, Neroli A Thomson

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