Evaluation of fetal femur length to detect Down syndrome in a Thai population

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Y TannirandornD Charoenvidhya

Abstract

To assess the value of femur length shortening for prenatal detection of Down syndrome in a Thai population. A prospective study was performed by experienced perinatologists on 3137 women undergoing second-trimester amniocentesis, between 16 and 24 weeks of gestation, for the indications of advanced maternal age and past history of chromosomal abnormality. Biparietal diameter and femur length measurements were obtained before the procedures. Regression equations relating biparietal diameter to femur length were used to calculate observed femur length/expected femur length ratio in the chromosomally normal and Down syndrome fetuses. Sensitivity, specificity, false-positive rate and likelihood ratio of a positive test result at various observed femur length/expected femur length ratios for detection of Down syndrome were calculated. A receiver-operator characteristic curve was used to determine threshold screening ratio. There were 3084 chromosomally normal pregnancies, 26 fetuses with Down syndrome (1:118), and 27 other chromosomal abnormalities. The relationship between femur length and biparietal diameter (BPD) was: expected femur length=-7.631+0.814 BPD, R(2)=0.78, P<0.001). Femur length in Down syndrome fetuses was significa...Continue Reading

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Jul 15, 1999·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Y TannirandornS Phaosavasdi

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Citations

Dec 18, 2001·Prenatal Diagnosis
Mar 3, 2009·Seminars in Fetal & Neonatal Medicine·A Michael Weindling
Mar 18, 2009·American Journal of Clinical Pathology·Maria A Proytcheva

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