Evaluation of Fisher Information Matrix-Based Methods for Fast Assessment of Image Quality in Pinhole SPECT

IEEE Transactions on Medical Imaging
Lara R V PatoRoel Van Holen

Abstract

The accurate determination of the local impulse response and the covariance in voxels from penalized maximum likelihood reconstructed images requires performing reconstructions from many noise realizations of the projection data. As this is usually a very time-consuming process, efficient analytical approximations based on the Fisher information matrix (FIM) have been extensively used in PET and SPECT to estimate these quantities. For 3D imaging, however, additional approximations need to be made to the FIM in order to speed up the calculations. The most common approach is to use the local shift-invariant (LSI) approximation of the FIM, but this assumes specific conditions which are not always necessarily valid. In this paper we take a single-pinhole SPECT system and compare the accuracy of the LSI approximation against two other methods that have been more recently put forward: the non-uniform object-space pixelation (NUOP) and the subsampled FIM. These methods do not assume such restrictive conditions while still increasing the speed of the calculations considerably. Our results indicate that in pinhole SPECT the NUOP and subsampled FIM approaches could be more reliable than the LSI approximation, especially when a high accur...Continue Reading

References

Oct 1, 1967·Physics in Medicine and Biology·D Paix
Oct 6, 2000·IEEE Transactions on Medical Imaging·J Qi, R M Leahy
Jun 15, 2004·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·William P SegarsStuart S Berr
Jul 14, 2004·Physics in Medicine and Biology·Bruno De Man, Samit Basu
Dec 4, 2004·IEEE Transactions on Medical Imaging·J Webster Stayman, Jeffrey A Fessler
Jan 1, 1990·IEEE Transactions on Medical Imaging·P J Green
Feb 13, 2008·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·J A Fessler, S D Booth
Feb 14, 2008·IEEE Transactions on Medical Imaging·K VunckxJ Nuyts
Jan 1, 1996·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·J A Fessler
Jan 1, 1996·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·J A Fessler, W L Rogers
Jul 5, 2008·IEEE Transactions on Medical Imaging·Kathleen VunckxJohan Nuyts
Mar 31, 2009·Methods : a Companion to Methods in Enzymology·Johan NuytsChristian Vanhove
Aug 13, 2013·IEEE Transactions on Medical Imaging· Jianyu Lin

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