Evaluation of FloSeal as a potential intracavitary hemostatic agent

The Journal of Trauma
Harold G Klemcke

Abstract

Noncompressible hemorrhage is a major cause of death in combat and civilian trauma. When surgery is unavailable, one potential solution to such hemorrhage might be the introduction of an agent into the closed body cavity to provide hemostasis via a combination of coagulative and tamponade effects. FloSeal is an agent containing collagen and thrombin with proven hemostatic efficacy when applied with manual pressure to a bleeding site. The current studies were conducted to analyze the ability of FloSeal to reduce blood loss and increase survival time when applied directly, immediately, and without additional pressure to a severe liver injury in rats. Male rats were anesthetized and catheters were placed in the carotid artery (for measurement of blood pressure) and jugular vein (for resuscitation with lactated Ringers, 3.3 mL/min/kg BW). After midventral laparotomy, the liver was exposed and caudal portions of both medial lobes ( approximately 1% of body weight) were rapidly excised. FloSeal (5 mL, 800 units Thrombin/mL) or vehicle (5 mL, 0.9% NaCl) was directly and immediately applied to the cut liver surface. The abdominal cavity was closed and resuscitation initiated. After hemorrhage-induced death, or after euthanasia at 90 mi...Continue Reading

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Citations

May 8, 2009·Langenbeck's Archives of Surgery·Mario TestiniGiuseppe Piccinni
May 14, 2010·World Journal of Surgical Oncology·Gianna PaceLucio Miano
Apr 25, 2015·Journal of Medical Economics·Guy DavidSanjoy Roy
Aug 28, 2012·The Journal of Surgical Research·Michael J DugganDavid R King
Sep 3, 2008·The British Journal of Surgery·H SeyednejadA M Seifalian
Jun 30, 2012·International Journal of Surgery Case Reports·Dimitrios DimitroulisGregory Kouraklis
Sep 23, 2006·Traffic Injury Prevention·Paul C IvancicGeorge F Malcolmson
Sep 9, 2010·Expert Review of Medical Devices·Henry T Peng, Pang N Shek
Mar 27, 2020·Military Medical Research·Henry T Peng
Apr 9, 2021·Journal of Applied Physiology·Harold G KlemckeCarmen Hinojosa-Laborde

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