Evaluation of flow properties of dry powder inhalation of salbutamol sulfate with lactose carrier

Chemical & Pharmaceutical Bulletin
Kotaro IidaHans Leuenberger

Abstract

The effects of the flow and packing properties of a drug/carrier powder mixture on emission of drug adhering to the carrier from capsules and inhalation devices were investigated. Model powder mixtures were designed consisting of lactose carriers with different particle shapes were prepared by surface treatment and micronized salbutamol sulfate. These powder mixtures were aerosolized by a Spinhaler, and in vitro deposition properties of salbutamol sulfate were evaluated by a twin impinger. The flow properties of the mixed powders were evaluated by the Carr's flowability index (FI) and Hausner's ratio (HR). The packing properties of the mixed powders were determined employing the tapping method. Compared with the powder mixed with the untreated lactose carrier, the FI, HR, and the constant K in Kawakita's equation of the powder mixture prepared using the surface-treated lactose carrier were significantly different, showing that the flow and packing properties of the drug/carrier powder mixture were improved. Using this surface-treated system, the handling of the powder mixture when packing into capsules is improved, which is desirable for handling dry powder inhalants. The fraction (%) of drug emitted from capsules and devices (...Continue Reading

References

Oct 1, 1976·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·A Otsuka, K Danjo

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Citations

Jan 10, 2003·Chemical & Pharmaceutical Bulletin·Kotaro IidaHans Leuenberger
Dec 4, 2003·Chemical & Pharmaceutical Bulletin·Kotaro IidaHans Luenbergerb
Apr 2, 2005·Chemical & Pharmaceutical Bulletin·Kotaro IidaHans Leuenberger
Feb 19, 2010·Expert Opinion on Drug Metabolism & Toxicology·Joshiah Gordon, Ralph J Panos
Mar 17, 2010·Journal of Pharmaceutical Sciences·Zhen XuAnthony J Hickey
Oct 29, 2009·Journal of Pharmaceutical Sciences·Meer Saiful Hassan, Raymond Lau
May 5, 2011·International Journal of Pharmaceutics·Meer Saiful Hassan, Raymond Lau
Feb 17, 2010·International Journal of Pharmaceutics·C P WatlingR E Cameron
Jan 20, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Philip F BuildersOlobayo O Kunle
Mar 9, 2013·International Journal of Pharmaceutics·Sarah ZellnitzNora Anne Urbanetz
Dec 27, 2011·International Journal of Pharmaceutics·Waseem KaialyAli Nokhodchi
Sep 29, 2011·International Journal of Pharmaceutics·Waseem KaialyAli Nokhodchi
Dec 29, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sarah ZellnitzAmrit Paudel
Aug 8, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jun Yee TseYuichi Tozuka

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